TABLE 1

Effects of antihypertensive drug classes on plasma vasoactive peptide levels and renin activity

Drug ClassAng IAng IIAng 1-7BK 1-9ANP, BNPPRCPRA
ARB↑↑==↑↑↑↑
ACEi↑↑↑↑=↑↑↑↑
C-ACEi↑↑==↑↑↑↑
NEPi==
ACEi/NEPi↑↑↑↑↑↑↑↑
ARNI↑↑=↑↑↑↑
AGT-siRNA↓↓↓↓↓↓==↑↑↓↓
DRI↓↓↓↓↓↓==↑↑↓↓
APAi=======
rhACE2↓↓↑↑↑==↑↑↑↑
  • Upward arrows indicate upregulation, downward arrows indicate downregulation, and equal signs indicate no change. ACEi, ACE inhibitor; ACEi/NEPi, dual ACE and NEP inhibitor; AGT-siRNA, angiotensinogen siRNA; APAi, amino peptidase A inhibitor; C-ACEi, C-domain–selective ACE inhibitor; DRI, direct renin inhibitor; NEPi, NEP inhibitor; PRA, plasma renin activity; PRC, plasma renin concentration.