Summary of findings in cell-specific STAT3–KO mice
| STAT3 KO in Cell | Phenotype | Reference |
|---|---|---|
| All cells | Embryonic lethal at 7 days | Takeda et al., 1997 |
| Keratinocytes | Impaired hair cycle and skin wound healing | Sano et al., 1999 |
| Respiratory epithelium | Impaired injury tolerance | Hokuto et al., 2004 |
| Intestinal epithelium | Impaired epithelial wound healing | Pickert et al., 2009 |
| Cardiomyocyte | Increased presbycardia and MI susceptibility | Jacoby et al., 2003; Hilfiker-Kleiner et al., 2004 |
| Hepatocytes | Insulin resistance; impaired liver regeneration | Inoue et al., 2004; Moh et al., 2007 |
| Adipocyte | Increased body weight and adiposity | Cernkovich et al., 2008 |
| Neural cells | Obesity, diabetes, infertility, and thermal dysregulation | Gao et al., 2004 |
| Hematopoietic progenitors | Unaltered basal hematopoiesis; impaired stem cell regeneration after 5-FU | Lee et al., 2002; Chung et al., 2006 |
| Hematopoietic-derived cells | Impaired DC function: defective transition of CMP/CLP to common DC precursors | Laouar et al., 2003 |
| Bone marrow cells | Impaired myeloid cells resulting in Crohn’s disease-like pathology | Welte et al., 2003 |
| T cells | Increased apoptosis and impaired Th17 development | Takeda et al., 1998b; Yang et al., 2007b |
| B cells | Reduced B cell compartments and plasma cells | Chou et al., 2006; Fornek et al., 2006 |
| Macrophages and neutrophils | High susceptibility to endotoxin shock, ↑ TNF-α, IL-1, and IFN-γ | Takeda et al., 1999 |
CLP, common lymphoid progenitor; 5-FU, fluorouracil.