(Pro)renin and the (pro)renin receptor [(P)RR] in the collecting duct: synthesis and effects, including effects that involve the soluble s(P)RR
| Synthesis | |
|---|---|
| (Pro)renin | ↑ after Ang II (Prieto-Carrasquero et al., 2004) |
| ↑ after low sodium (Rohrwasser et al., 1999) | |
| ↑ after hyperglycemia (Kang et al., 2008) | |
| (P)RR | ↑ after Ang II (Gonzalez et al., 2011, 2014b; Wang et al., 2014) |
| ↑ after low sodium (Quadri and Siragy, 2014) | |
| ↑ or = after hyperglycemia (Ichihara et al., 2008; Matavelli et al., 2010) | |
| Effects (P)RR | |
| Water transport | ↑ via Ang II or Ang II–independent (Song et al., 2013; Ramkumar et al., 2015; Lu et al., 2016b; Wang et al., 2016) |
| Sodium reabsorption | ↑ partly via Ang II (Ramkumar et al., 2015, 2016b, 2018; Lu et al., 2016a,b; Quadri and Siragy, 2016) |
| Fibrosis | ↑ Ang II–independent (Reyes-Martinez et al., 2019) |
| Urinary acidification | ↑ (pro)renin-independent (Trepiccione et al., 2016) |
| Effects s(P)RR | |
| Water transport | ↓ in a polyuria model (Lu et al., 2016b; Wang et al., 2019) |
| Sodium reabsorption | ↑ via ENaC (Wang et al., 2020; Feng et al., 2021) |
| Blood pressure | ↑ during Ang II infusion (Ramkumar et al., 2021) |