Regular ArticleBiosynthesis of 9-cis-Retinoic Acid from 9-cis-β-Carotene in Human Intestinal Mucosa in Vitro
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Carotenoid metabolism at the intestinal barrier
2020, Biochimica et Biophysica Acta - Molecular and Cell Biology of LipidsCitation Excerpt :Notably, Jim Olson's group previously obtained a similar result with cell free extracts of rat intestine [192], indicating that BCO1 possesses intrinsic isomerase activity. This finding contrasts with reports suggesting that 9-cis-β-carotene is converted to 9-cis-retinal and all-trans-retinal in one to one molar ratio [193,194]. It also contrasts the more recent proposal that 9-cis-β-carotene is not enzymatically converted by recombinant human BCO1 [88].
Role of macular xanthophylls in prevention of common neovascular retinopathies: Retinopathy of prematurity and diabetic retinopathy
2015, Archives of Biochemistry and BiophysicsCitation Excerpt :The major central cleavage pathway, via β-carotene 15,15′-monooxygenase or BCO1, generates retinoids from provitamin A carotenoids [110–113], such as α- and β-carotene and β-cryptoxanthin. An alternative eccentric cleavage pathway is catalyzed by β-carotene 9′,10′-dioxygenase or BCO2 [114–116]. BCO2 is expressed in several tissues not known to be sensitive to vitamin A deficiency and/or that lack BCO1 expression [117].
Substrate specificity of purified recombinant human β-carotene 15,15′-oxygenase (BCO1)
2013, Journal of Biological ChemistryCitation Excerpt :These isomers have also been detected in human plasma (19, 20). Cleavage activity with these β-carotene isomers have been shown by incubation with intestine and liver homogenates (14, 21, 22). However, the use of cell homogenates to study enzymatic oxidation of carotenoids in vitro is problematic.
Effects of Chinese domestic cooking methods on the carotenoid composition of vegetables in Taiwan
2012, LWTCitation Excerpt :However, we have no explanation for the decrease of (9Z)-zeaxanthin in Thai basil leaf after 10 min of boiling, it might be due to different tissue features. Compared with (all-E)-β-carotene, (9Z)-β-carotene is a less efficient precursor of vitamin A. However, a possible metabolic conversion of (9Z)-β-carotene to (9Z)-retinoic acid has been proposed (Wang, Krinsky, Benotti, & Russell, 1994) and is considered as a potential medication in certain types of tumours (Mertz et al., 1997). As a result, (9Z)-β-carotene has received a lot of attention, since it has the potential to inhibit the progression of tumours in humans.
β-carotene is an important vitamin A source for humans
2010, Journal of NutritionHuman nutritional relevance and suggested nutritional guidelines for vitamin A5/X and provitamin A5/X
2023, Nutrition and Metabolism