Regular ArticleMolecular Cloning of the Human Histamine H1 Receptor Gene
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Expression and localization of histamine H<inf>1</inf>, H<inf>2</inf>, and H<inf>3</inf> receptors in rat olfactory epithelium
2017, International Journal of Pediatric OtorhinolaryngologyCitation Excerpt :Histamine stored in mast cells and basophils has been recognized as one of the most critical mediators in allergic reactions and plays an important role in eliciting the nasal symptoms of allergic rhinitis, such as sneezing, nasal itch, pain, rhinorrhea, and congestion [1,2]. It is now clear that histamine exerts its diverse biological effects by binding to and activating four separate G protein-coupled receptors, referred to as histamine H1 receptor (H1R) [3], histamine H2 receptor (H2R) [4], histamine H3 receptor (H3R) [5], and histamine H4 receptor (H4R) [6]. These four histamine receptor subtypes differ in their tissue distribution, agonist- and antagonist-binding affinities, structures, and functions.
Calcium influx and release mechanism(s) in histamine-induced myometrial contraction in buffaloes
2014, Animal Reproduction ScienceExperimental and quantum-chemical studies of histamine complexes with copper(II) ion
2012, PolyhedronCitation Excerpt :Using IR and Raman spectroscopy it was determined that at alkaline pH the water-insoluble polymer (Cu–HistH−1)n and the water-soluble monomers Cu–Hist or Cu–(Hist)2 are dominant [26]. The interaction of the transition metal ion complexes with histamine could play a key role in the physiological activity of this biological ligand [17–21]. The formation of the Cu(II)–histamine complexes could have an effect on the interaction of metal with proteins in the enzymatic reactions.
Pharmacology of Antihistamines
2011, World Allergy Organization JournalCitation Excerpt :This superfamily represents at least 500 individual membrane proteins that share a common structural motif of 7 transmembrane α-helical segments7, 8 (Figure 1A). The histamine H1-receptor gene encodes a 487 amino acid protein with a molecular mass of 55.8 kDa9, 10. The absence of introns in the H1-receptor gene indicates that only a single receptor protein is transcribed with no splice variants10.