Biochemical and Biophysical Research Communications
Regular ArticleMapping Studies of Two G Protein-Coupled Receptor Genes: An Amino Acid Difference May Confer a Functional Variation Between a Human and Rodent Receptor
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The influence of selection in wild pheasant (Phasianus colchicus) breeding on reproduction and the involvement of the chemerin system
2023, Poultry ScienceCitation Excerpt :Chemerin exerts its main biological functions through binding to its main G protein-coupled receptor chemokine-like receptor 1 (CMKLR1)(Gantz et al., 1996). This adipokine is also able to bind 2 others receptors which are GPR1 (G protein coupled receptor 1) and CCRL2 (CC motif chemokine receptor like 2)(Marchese et al., 1994; Shimada et al., 1998). In birds, few data are available about chemerin's role in metabolism and reproduction.
GPR3 accelerates neurite outgrowth and neuronal polarity formation via PI3 kinase-mediating signaling pathway in cultured primary neurons
2022, Molecular and Cellular NeuroscienceCitation Excerpt :GPR3 makes up a subfamily with GPR6 and GPR12. These are all highly expressed neuronal receptors that share the similar feature of a constitutive elevation of intracellular cAMP without the presence of a ligand (Eggerickx et al., 1995; Ignatov et al., 2003; Marchese et al., 1994; Saeki et al., 1993; Tanaka et al., 2007). Although the developmental expression of GPR6 and GPR12 in hippocampal neurons remains elusive, it is possible that their redundant mechanism for polarity formation might be involved in the development of hippocampal neurons.
Extranuclear signaling by ovarian steroids in the regulation of sexual receptivity
2018, Hormones and BehaviorCitation Excerpt :Although OFQ/N mediates facilitation of lordosis by both the high single-dose and sequential treatments of estradiol, it is unclear whether the high dose signals through GPER to induce OFQ/N release (Chokr et al., 2016; Long et al., 2015; Sanathara et al., 2011; Sanathara et al., 2014). During the 1990's another opioid receptor was cloned, the ORL-1 (Bunzow et al., 1994; Chen et al., 1994; Fukuda et al., 1994; Lachowicz et al., 1995; Marchese et al., 1994; Mollereau et al., 1994; Wang et al., 1994; Wick et al., 1994). Its endogenous ligand, OFQ/N, is a heptadecapeptide (Meunier et al., 1995; Reinscheid et al., 1995; Saito et al., 1996; Saito et al., 1995).
Orphan peptide and G protein-coupled receptor signalling in alcohol use disorder
2024, British Journal of PharmacologyMolecular insights into orphan G protein-coupled receptors relevant to schizophrenia
2023, British Journal of Pharmacology