Regular ArticleThe Human Bradykinin B2 Receptor Gene: Full-Length cDNA, Genomic Organization and Identification of the Regulatory Region
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G Protein-Coupled Kinin Receptors and Immunity Against Pathogens
2017, Advances in ImmunologyCitation Excerpt :In the early 1980s, Regoli and Barabé (1980) distinguished the existence of two kinin receptors based on differences of agonist potencies and synthesis of subtype-specific synthetic antagonists further validated their predictions (Vavrek & Stewart, 1985). Gene cloning in the 1990s led to the characterization of kinin receptors as members of the large rhodopsin family of GPCRs containing seven-membrane-spanning domains (Hess, Borkowski, Young, Strader, & Ransom, 1992; Kammerer, Braun, Arnold, & Roscher, 1995; McEachern et al., 1991; McIntyre, Phillips, Skidmore, Brown, & Webb, 1993; Pesquero et al., 1994, 1996). Insight on the functional role of B2R and B1R came with the development of knockout mice for each subtype of kinin receptors (Borkowski et al., 1995; Cayla et al., 2007; Pesquero et al., 2000).
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