Regular ArticleGastric Inhibitory Polypeptide Activates MAP Kinase through the Wortmannin-Sensitive and -Insensitive Pathways
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2022, Pharmacology and TherapeuticsCitation Excerpt :GIPR primarily activates cAMP signaling and shows high constitutive cAMP activity (Fortin et al., 2010). Moreover, GIPR also activates MAPK pathway (Kubota et al., 1997) and phosphatidylinositol 3-kinase/protein kinase B pathway (Trumper et al., 2001). In addition, the GIPR has been shown to undergo homologous desensitization, in which β-arrestin 1 and G protein-coupled receptor kinase are implicated (Tseng & Zhang, 1998, 2000).
GIP
2013, Handbook of Biologically Active PeptidesTargeting the glucagon receptor family for diabetes and obesity therapy
2012, Pharmacology and TherapeuticsTwo incretin hormones GLP-1 and GIP: Comparison of their actions in insulin secretion and β cell preservation
2011, Progress in Biophysics and Molecular BiologyCitation Excerpt :Later, proliferative effects were also demonstrated of GIPR activation in INS-1 cells (Bocker and Verspohl, 2001; Trumper et al., 2001). It has been shown that GIP activates the Raf-Mek1/2-ERK1/2 signaling module through cAMP/PKA signaling in GIPR-overexpressing CHO cells (Trumper et al., 2001; Ehses et al., 2002; Kubota et al., 1997) (Fig. 5). Consistent with these observations, PKA and MEK inhibitors have been shown to prevent GIP-induced proliferation of cultured islet cells (Friedrichsen et al., 2006).