Biochemical and Biophysical Research Communications
Regular ArticleFunctional Association between CBP and HNF4 inTrans-activation
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IRF2BP2 is a novel HNF4α co-repressor: Its role in gluconeogenic gene regulation via biochemically labile interaction
2022, Biochemical and Biophysical Research CommunicationsCitation Excerpt :The expression plasmid for full-length HNF4α cDNA was cloned as previously described [4]. 8xHNF4 binding site-tk Luc vector, which contains eight copies of the HNF4-binding site was kindly provided by Dr. Akiyoshi Fukamizu (University of Tsukuba) [22]. Antibodies for Western blot included anti-HNF4α (3113S, Cell Signaling Technology, Danvers, MA), anti-IRF2BP2 (18847-1-AP, Proteintech, Rosemont, IL) and Actin (I-19, Santa Cruz, Santa Cruz, CA).
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2011, Biochimica et Biophysica Acta - Molecular Basis of DiseaseMultiple post-translational modifications in hepatocyte nuclear factor 4α
2011, Biochemical and Biophysical Research CommunicationsDAX-1 acts as a novel corepressor of orphan nuclear receptor HNF4α and negatively regulates gluconeogenic enzyme gene expression
2009, Journal of Biological ChemistryRole of epigenetics in liver-specific gene transcription, hepatocyte differentiation and stem cell reprogrammation
2009, Journal of HepatologyCitation Excerpt :In this context, the transcriptional activation of LETFs critically depends on the recruitment of co-activator proteins with intrinsic HAT activity, such as CREB-binding protein (CBP), p300/CBP-associated factor (P/CAF) and SRC1, whereas co-repressor complexes containing HDAC negatively regulate liver-specific gene expression [86–107]. In detail, HNF-4α, directly interacts with SRC1, CBP and p300, resulting in its increased transcriptional activity [86–92]. The level of upregulation is isoform-dependent [92,93].
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To whom correspondence should be addressed at Institute of Applied Biochemistry, University of Tsukuba, Ibaraki 305, Japan. Fax: 81-298-53-6599. E-mail: [email protected].