Biochemical and Biophysical Research Communications
Regular ArticleHyperlipidemia Induced by High Cholesterol Diet Inhibits Heat Shock Response in Rat Hearts
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Cited by (55)
Influence of cardiometabolic comorbidities on myocardial function, infarction, and cardioprotection: Role of cardiac redox signaling
2021, Free Radical Biology and MedicineDecreased effectiveness of ischemic heart preconditioning in the state of chronic inflammation
2015, Medical HypothesesCitation Excerpt :We believe, that our hypothesis is consistent with the results of the previously published studies on IPC in elderly, diabetes, hyperlipidemia and heart failure, where different steps of signal transduction pathway have been found to be deficient or inactive. It is possible, that decreased activity of hexokinase-II or PI3K–Akt, reduced levels of PKC, diminished the expression of heat shock proteins, dysfunction of mitochondrial KATP channels or decreased mitochondrial connexin 43 content may be the result of their down-regulation and desensitization because of prolonged activation [68,91,100]. We also suggest, that accordingly to the threshold hypothesis, an attenuated signal transduction cascade could be overcome by strengthening the preconditioning stimulus [104,115].
Dietary lipid levels in meagre (Argyrosomus regius): Effects on biochemical and molecular indicators of liver
2014, AquacultureCitation Excerpt :Probably, the high content of polyunsaturated fatty acids (PUFA) of high lipid diets can induce the Hsp response, since PUFA are more susceptible to reactive oxygen species (ROS) (Ibarz et al., 2010). On the contrary, hyperlipidemia caused by high cholesterol diet inhibited heat shock response in male Wistar rats (Csont et al., 2002). In teleosts, feed deprivation induces Hsp70 and Hsp90 protein expression in sea bream (Sparus aurata) and rainbow trout (Oncorhychus mykiss) according to Cara et al. (2005).
Pre-and post-conditioning of the heart: An overview of cardioprotec-tive signaling pathways
2021, Current Vascular PharmacologyHyperlipidaemia and cardioprotection: Animal models for translational studies
2020, British Journal of Pharmacology
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