Elsevier

Cytokine

Volume 12, Issue 7, July 2000, Pages 1104-1109
Cytokine

Short Communication
IGF-II AND IL-2 ACT SYNERGISTICALLY TO ALTER HDAC1 EXPRESSION FOLLOWING TREATMENTS WITH TRICHOSTATIN A

https://doi.org/10.1006/cyto.2000.0680Get rights and content

Abstract

Histone deacetylases play key roles in the regulation of gene transcription. Studies have shown that expression of interleukins IL-2 and IL-8, and insulin-like growth factor 2 (IGF2) are affected by treatment with histone deacetylase inhibitors. We have previously shown that the gene for histone deacetylase 1 (HDAC1) is upregulated following treatment with TSA. The murine homologue of this gene has been reported to be inducible by IL-2. In this study, we have examined the effects IL-2, IGF-II and TSA have on HDAC1 expression in the human hepatocellular carcinoma derived cell line Hep3B. Our results indicate that in contrast to the mouse, HDAC1 is not inducible by IL-2. However, in TSA treated cells, IL-2 and IGF-II were found to act synergistically to reduce TSA induced HDAC1 mRNA levels almost to normal.

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Correspondence to: Dr Tomas J. Ekström, Laboratory for Molecular Development and Tumor Biology, Experimental Alcohol and Drug Addiction Research Section, Dept. of Clinical Neuroscience, Karolinska Institute, CMM L8:01, S-171 76 Stockholm, Sweden; E-mail:[email protected]

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