Regular ArticleNuclear Localization of the Tight Junction Protein ZO-2 in Epithelial Cells
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2017, Biochimica et Biophysica Acta - Molecular Cell ResearchCitation Excerpt :ZO-2 is a 160 kD MAGUK protein with a dual localization. Thus in quiescent epithelial cells ZO-2 is present at the TJ, whereas in proliferating cells it localizes both at the TJ and the nucleus [28]. At the nucleus, ZO-2 accumulates in speckles, co-localizes with the essential splicing factor SC-35, and inhibits gene transcription by association to molecular complexes formed by transcription factors and histone deacetylases [29,30].
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