Elsevier

Experimental Neurology

Volume 146, Issue 2, August 1997, Pages 553-559
Experimental Neurology

Regular Article
Enhancement by an Ampakine of Memory Encoding in Humans

https://doi.org/10.1006/exnr.1997.6581Get rights and content

Abstract

A centrally active drug that enhances AMPA receptor-mediated currents was tested for its effects on memory in humans. Evidence for a positive influence on encoding was obtained in four tests: (i) visual associations, (ii) recognition of odors, (iii) acquisition of a visuospatial maze, and (iv) location and identity of playing cards. The drug did not improve scores in a task requiring cued recall of verbal information. The selectivity of drug effects on memory was confirmed using tests of visual recognition, motor performance, and general intellectual functioning. These results suggest that positive modulators of AMPA receptors selectively improve at least some aspects of memory.

References (27)

  • A. Arai et al.

    Effects of a memory enhancing drug on AMPA receptor currents and synaptic transmission in hippocampus

    J. Pharm. Exp. Ther.

    (1996)
  • T.V.P. Bliss et al.

    Long-lasting potentiation of synaptic transmission in the dentate area of the anaesthetized rabbit following stimulation of the perforant path

    J. Physiol.

    (1973)
  • C.M. Davis et al.

    A profile of the behavioral changes produced by facilitation of AMPA-type glutamate receptors

    Psychopharmacology.

    (1997)
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