Short CommunicationCloning and Chromosomal Localization of the Human A2b Adenosine Receptor Gene (ADORA2B) and Its Pseudogene
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Kinetic profiling and functional characterization of 8-phenylxanthine derivatives as A<inf>2B</inf> adenosine receptor antagonists
2022, Biochemical PharmacologyCitation Excerpt :The A2B adenosine receptor (A2BAR) belongs to the superfamily of rhodopsin-like G protein-coupled receptors (GPCRs), being a member of the adenosine receptor (AR) family. It has been mapped on chromosome 17p11.2-12, and as all GPCRs the encoded protein consists of a seven transmembrane (7TM) α-helix architecture [1,2]. Adenosine, a ubiquitous purine nucleoside, is the endogenous ligand for all ARs, i.e. A1, A2A, A2B and A3.
The resurgence of A2B adenosine receptor signaling
2011, Biochimica et Biophysica Acta - BiomembranesIdentification of nuclear factor 1 (NF1) as a transcriptional modulator of rat A<inf>2A</inf> adenosine receptor
2003, Molecular Brain ResearchThe adenosine 2b receptor is recruited to the plasma membrane and associates with E3KARP and ezrin upon agonist stimulation
2002, Journal of Biological ChemistryCitation Excerpt :Our data is in agreement with others who, using antibody to another epitope in the A2bR, observed that the A2bR had a similar molecular mass of 42 kDa (32, 33) in human lymphocytes and CHO cells transfected with the native receptor. The A2bR is known to have two promoters and in addition, a pseudogene located on chromosome 1 (34). Alternate splicing resulting in protein sequence heterogeneity similar to that observed in several other receptors such as dopamine receptor; EP3 receptor has been proposed for the A2bR (3).
The role of receptor structure in determining adenosine receptor activity
2000, Pharmacology and TherapeuticsAltered gene expression in melanocytes exposed to 4-tertiary butyl phenol (4-TBP): Upregulation of the A2b adenosine receptor
1999, Journal of Investigative Dermatology