Regular ArticleThe Structures of the Mouse and Human Urocortin Genes (Ucn and UCN)☆
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2022, Neuroscience LettersCitation Excerpt :Interestingly, recent work has demonstrated that stimulation of the Crh system within the amygdala can promote reward consumption, so a decrease in Crh may be associated with a negative affective state of withdrawal [47]. In addition, Ucn3 is associated with food regulation during negative affective states such as withdrawal, so increased Ucn3 within the amygdala may partially underlie the reduced weight gain observed in females at the 48 h time point [36,37]. Taken together with increased corticosterone observed at this time, these data support the hypothesis that the stress associated with withdrawal may be exacerbated in Mor-F1 females.
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Mouse Ucn and human UCN gene sequences have been deposited with the EMBL/GenBank Data Libraries under Accession Nos. AF038632 and AF038633, respectively.
- 1
Current address: Animal Science Department, Michigan State University, East Lansing, MI 48824-1225.
- 2
To whom correspondence should be addressed at The Clayton Foundation Laboratories for Peptide Biology, The Salk Institute, 10010 North Torrey Pines Road, La Jolla, CA 92037. Telephone: (619) 453-4100. Fax: (619) 552-1546.