Regular ArticleGenomic Organization and Partial Duplication of the Human α7 Neuronal Nicotinic Acetylcholine Receptor Gene (CHRNA7)☆
References (76)
- et al.
Regulated expression of the human corticotropin releasing hormone gene by cyclic AMP
Mol. Cell. Endocrinol.
(1990) - et al.
Normalization by nicotine of deficient auditory sensory gating in the relatives of schizophrenics
Biol. Psych.
(1992) - et al.
Agonist pharmacology of the neuronal α7 nicotinic receptor expressed inXenopus
FEBS
(1993) - et al.
Restoration of sensory gating of auditory evoked response by nicotine in fimbria–fornix lesioned rats
Brain Res.
(1995) - et al.
Identification of novel exons 3′ to the humanSNRPN
Genomics
(1997) - et al.
Genomic variation and gene conversion in spinal muscular atrophy: Implications for disease process and clinical phenotype
Am. J. Hum. Genet.
(1997) - et al.
Single-step method of RNA isolation by acid guanidinium thiocynanate–phenol–chloroform extraction
Anal. Biochem.
(1987) - et al.
A neuronal nicotinic acetylcholine receptor subunit α7 is developmentally regulated and forms a homo-oligomeric channel blocked by α-BTX
Neuron
(1990) - et al.
Alpha 9: An acetylcholine receptor with novel pharmacological properties expressed in rat cochlear hair cells
Cell
(1994) - et al.
Evidence in postmortem brain tissue for decreased numbers of hippocampal nicotinic receptors in schizophrenia
Biol. Psych.
(1995)
Elementary neuronal dysfunctions in schizophrenia
Schiz. Res.
(1991)
Early growth response protein 1 (Egr-1): Prototype of a zinc-finger family of transcription factors
Prog. Nucleic Acid Res. Mol. Biol.
(1995)
Members of a nicotinic acetylcholine receptor gene family are expressed in different regions of the mammalian central nervous system
Cell
(1987)
Cyclic AMP stimulates somatostatin gene transcription by phosphorylation of CREB at serine 133
Cell
(1989)
Duplication of seven exons in the LDL receptor gene caused by Alu–Alu recombination in a subject with familial hypercholesterolemia
Cell
(1987)
Cholinergic gating of response to auditory stimuli in rat hippocampus
Brain Res.
(1992)
Brain α-bungarotoxin binding protein cDNAs and MAbs reveal subtypes of this branch of the ligand-gated ion channel gene superfamily
Neuron
(1990)
Genetic correlation of inhibitory gating of hippocampal auditory evoked response and α-bungarotoxin-binding nicotinic cholinergic receptors in inbred mouse strains
Brain Res.
(1996)
Nicotinic receptors that bind α-bungarotoxin on neurons raise intracellular free Ca2+
Neuron
(1992)
Neuronal acetylcholine receptors that bind α-bungarotoxin with high affinity function as ligand-gated ion channels
Neuron
(1994)
Ligand-induced differentiation of glucocorticoid receptor (GR) transrepression and transactivation
Biochem. Soc. Trans.
(1996)
Normalization of auditory physiology by cigarette smoking in schizophrenic patients
Am. J. Psych.
(1993)
Proc. Natl. Acad. Sci. USA
(1990)
Diversity of nicotinic acetylcholine receptors in rat hippocampal neurons. I. Pharmacological and functional evidence for distinct structural subtypes
J. Pharmacol. Exp. Ther.
(1993)
PCR amplification of up to 35 kb DNA with high fidelity and high yields from lambda templates
Proc. Natl. Acad. Sci. USA
(1994)
The human muscle nicotinic acetylcholine receptor α-subunit exists as two isoforms: A novel exon
EMBO J.
(1990)
Negative regulatory elements upstream of a novel exon of the neuronal nicotinic acetylcholine receptor alpha 2 subunit gene
Nucleic Acids Res.
(1993)
Mutational analysis of muscle nicotinic acetylcholine receptor subunit assembly
J. Cell Biol.
(1990)
Molecular cloning of human gastric cDNA: Evidence for evolution of gastrin by gene duplication
Proc. Natl. Acad. Sci. USA
(1983)
Comparison of the regional expression of nicotinic acetylcholine receptor α7 mRNA and [125
J. Comp. Neurol.
(1997)
Isolation of single-copy human genes from a library of yeast artificial chromosome clones
Science
(1989)
Cloning of large segments of exogenous DNA into yeast by means of artificial chromosome vectors
Science
(1987)
Identification and characterization of the Egr-1 gene product, a DNA-binding zinc finger protein induced by differentiation and growth signals
Mol. Cell. Biol.
(1990)
Integrated YAC contig map of the Prader-Willi/Angelman region on chromosome 15q11–q13 with average STS spacing of 35 kb
Genome Res.
(1998)
Continuum of overlapping clones spanning the entire human chromosome 21q
Nature
(1992)
Modulation of nicotine receptors by chronic exposure to nicotinic agonists and antagonists
Ciba Found. Symp.
(1990)
Brain and muscle nicotinic acetylcholine receptors are different but homologous proteins
Proc. Natl. Acad. Sci. USA
(1985)
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Sequence data from this article have been deposited with the GenBank Data Library under Accession Nos. AF029837, AF029838, AF029839, AF036903, and AF037646.
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To whom correspondence should be addressed at Department of Psychiatry, Box C-268-71, University of Colorado Health Sciences Center, 4200 E. 9th Avenue, Denver, CO 80262. Telephone: (303) 315-8412. Fax: (303) 315-5347. E-mail:[email protected].
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