Regular ArticleAdditional 5′ Exons in the RGS3 Locus Generate Multiple mRNA Transcripts, One of Which Accounts for the Origin of Human PDZ-RGS3
References (23)
- et al.
G proteins
Trends Biochem. Sci.
(1992) Heterotrimeric G proteins: organizers of transmembrane signals
Cell
(1995)Heterotrimeric G protein signaling: roles in immune function and finetuning by RGS proteins
Immunity
(1998)Emerging roles for RGS proteins in cell signalling
Trends Pharmacol. Sci.
(1999)- et al.
A truncated form of RGS3 negatively regulates G protein-coupled receptor stimulation of adenylyl cyclase and phosphoinositide phospholipase C
J. Biol. Chem.
(1997) Regulator of G protein signaling RGS3T is localized to the nucleus and induces apoptosis
J. Biol. Chem.
(2000)Regulation of chemotactic and proadhesive responses to chemoattractant receptors by RGS (regulator of G-protein signaling) family members
J. Biol. Chem.
(1998)RGS3 inhibits Gβ1α2 induced inositol phosphate production, mitogen activated protein kinase activation, and Akt activation
J. Biol. Chem.
(2001)- et al.
Ephrin-B reverse signaling is mediated by a novel PDZ-RGS protein and selectively inhibits G protein-coupled chemoattraction
Cell
(2001) - et al.
C2PA, a new protein expressed during mouse spermatogenesis
FEBS Lett.
(2000)
Cited by (32)
Emerging Roles of Regulators of G Protein Signaling (RGS) Proteins in the Immune System
2017, Advances in ImmunologyCitation Excerpt :Further mechanistic studies of T cell migration patterns at baseline and during inflammatory pathology will need to be done to determine the functions of RGS2 in adaptive immune responses. Unlike other members of the R4 subfamily that consist of little more than the RGS domain, RGS3 has several splice variants including a larger protein containing a PDZ motif, which has been shown to bind B-ephrin receptors to modulate their signaling (Kehrl, Srikumar, Harrison, Wilson, & Shi, 2002; Lu, Sun, Klein, & Flanagan, 2001). RGS3 was upregulated in splenic Th1 and Th2 cells differentiated from naïve splenocytes in vitro, and RGS3 KD augmented chemotaxis of T cell lines (EL4) to CXCL12 and CCL19 (Williams et al., 2013).
The impact of RGS and other G-protein regulatory proteins on Gα<inf>i</inf>-mediated signaling in immunity
2016, Biochemical PharmacologyCitation Excerpt :There are several RGS3 splice variants that encode for proteins with additional domains. One variant termed PDZ-RGS3 has N terminal PDZ domain, which can bind type B ephrins, an ATP/GTP-binding site, and a proline-rich region of unknown function [97,98]. A loss of PDZ-RGS3 in mice caused an early cell cycle exit and precocious differentiation of neural progenitor cells located in the developing cerebral cortex, a phenotype similar to that observed in the ephrin-B1 knockout mice.
Regulators of G-Protein-Signaling Proteins: Negative Modulators of G-Protein-Coupled Receptor Signaling
2015, International Review of Cell and Molecular BiologyCitation Excerpt :RGS3 has several spliced variant forms that all come from the RGS3 gene. A short form, RGS3S, which contains little more than the RGS domain, was expressed in the nucleus and induced apoptosis when overexpressed (Dulin et al., 2000; Jaen and Doupnik, 2005; Kehrl et al., 2002; Tosetti and Dunlap, 2004). RGS3 has two longer isoforms, RGS3L and PDZ-RGS3 (Kehrl et al., 2002), the latter of which has been linked to cell migration through interaction with Ephrin receptors and in Gβγ-evoked signaling.
Regulator of G-protein signaling 3 isoform 1 (PDZ-RGS3) enhances canonical Wnt signaling and promotes epithelial mesenchymal transition
2012, Journal of Biological ChemistryCitation Excerpt :Whereas full-length PDZ-RGS3 increased the levels of cytosolic β-catenin and c-myc, the RGS domain or PDZ domain-deleted versions had much less effect (Fig. 2A). We also compared PDZ-RGS3 with RGS3L, which contains the C-terminal 519 amino acids of PDZ-RGS3 (16). Expression of PDZ-RGS3 increased cyclin D1, another Wnt target gene (23), and c-myc whereas RGS3L expression had only a modest effect despite its much higher expression (Fig. 2B).
Regulators of G protein signaling proteins as targets for drug discovery
2010, Progress in Molecular Biology and Translational ScienceChapter 2 Insights into RGS Protein Function from Studies in Caenorhabditis elegans
2009, Progress in Molecular Biology and Translational ScienceCitation Excerpt :Proteins of the B/R4 family, often considered a mammal‐specific family, in general have no features outside the RGS domain. The one exception is human RGS‐3, which has an alternative isoform known as C2PA‐RGS‐3, that also contains a C2 domain.15 C. elegans RGS‐7 also has a C2 domain16 and we have therefore assigned it to the B/R4 family.
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