Original ArticleModulation of Cardiac Sarcoplasmic Reticulum Ryanodine Receptor by Sphingosine
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Sphingolipid-mediated calcium signaling and its pathological effects
2018, Biochimica et Biophysica Acta - Molecular Cell ResearchCitation Excerpt :We and others have shown that sphingosine potently blocks calcium entry through L-type voltage-operated calcium channels (VOCCs) in both cardiac and pituitary cells [79–82]. Furthermore, sphingosine is an efficient inhibitor of ryanodine receptors [83]. It is interesting to note, that sphingosylphosphorylcholine, a closely related lipid, enhances calcium release from ryanodine receptors [84].
Tuning of membrane electrostatic properties by single chain sphingolipids sphingosine and sphingosine-1-phosphate: The effect on bilayer dipole potential
2015, Colloids and Surfaces A: Physicochemical and Engineering AspectsCitation Excerpt :Second, the dipole potential has also been shown to affect the activity of transmembrane proteins such as Na+, K+ ATPase [20]. In this regard, Sph has been show to modulate the activity of the cardiac sarcoplasmic reticulum ryanodine receptor [43] whereas S1P has been reported to influence Ca2+ release from the endoplasmic reticulum, which involves Ca2+ channels as well as to transactivate VEGF receptors [6]. Direct electrostatic modulation of intrinsic proteins by dipole potential variations elicited by single-chain sphingolipids might be involved in such cellular effects.
Lysophospholipid Receptors
2013, Encyclopedia of Biological Chemistry: Second EditionEffects of endotoxic shock on neuronal NOS and calcium transients in rat cardiac myocytes
2005, Pharmacological ResearchMECHANISMS OF CARDIAC DYSFUNCTION IN SEPSIS
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