Regular ArticleElectrophysiological Basis for the Enhanced Cardiac Arrhythmogenic Effect of Isoprenaline in Aged Spontaneously Hypertensive Rats
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The rationale for repurposing funny current inhibition for management of ventricular arrhythmia
2021, Heart RhythmCitation Excerpt :Although increased expression of both HCN4 and HCN2 is noted, HCN4 is the predominant isoform in failed human ventricular myocardium.56 Altered HCN expression is associated with increased density funny current and generation of spontaneous diastolic depolarization in the ventricle.56–58 The funny current in diseased ventricular myocardium is of larger amplitude, is activated in less hyperpolarized membrane potential, deactivates slowly, and is more sensitive to adrenergic stimulation compared to cardiomyocytes from control heart.56
How cardiomyocyte excitation, calcium release and contraction become altered with age
2015, Journal of Molecular and Cellular CardiologyCitation Excerpt :By contrast, there is general agreement that age causes a prolongation in AP duration at 50% repolarization (APD50) ([18,38,74–77,79,81] but c.f. [40,78,82]). Furthermore, virtually all investigations report an age-associated increase in AP duration at 90% repolarization (APD90) in ventricular myocyte and tissues from male rats ([19,38,74,76–78,80–82] but c.f. [40]). A similar pattern is seen in ventricular myocytes from aged female sheep [71] but not rabbits [70].
Increased mechanically-induced ectopy in the hypertrophied heart
2012, Progress in Biophysics and Molecular BiologyCitation Excerpt :A better approach to manipulation of calcium handling mechanisms is needed than the use of isoprenaline in our experiments. In the presence of isoprenaline, SHR are reported to be more prone to DAD type arrhythmias due to Ca2+ overload (Barbieri et al., 1994). It is therefore logical that in this pro-arrhythmic state stretch more easily triggers ectopics.
Expression of hyperpolarization-activated cyclic nucleotide-gated cation channel (HCN4) is increased in hypertrophic cardiomyopathy
2011, Cardiovascular PathologyCitation Excerpt :In human hearts, the main HCN isoforms are HCN2 and HCN4 [11–14]. In failing human hearts, HCN4 was the predominant channel isoform, and the up-regulation may contribute to the ventricular and atrial arrhythmogenesis in heart failure [15,16]. In this study, we obtained ventricular samples from HCM and normal hearts and quantified the expression levels of HCN4 mRNA using the real-time reverse transcriptase (RT) PCR assay with SYBR Green dye.
Fetal bovine serum enables cardiac differentiation of human embryonic stem cells
2007, DifferentiationI<inf>f</inf> in non-pacemaker cells: Role and pharmacological implications
2006, Pharmacological Research