FeatureSarcoplasmic Reticulum Genes Are Upregulated in Mild Cardiac Hypertrophy But Downregulated in Severe Cardiac Hypertrophy Induced by Pressure Overload☆
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Calcium dysregulation in heart diseases: Targeting calcium channels to achieve a correct calcium homeostasis
2022, Pharmacological ResearchCitation Excerpt :A similar scenario is caused by the impaired action of PMCA and actomyosin, the other two ATP consuming proteins. It follows the absence of transients and a diminished contractility of the heart [133,134]. Nevertheless, other mechanistic insights are suggested in the literature.
Ouabain-induced hypertension enhances left ventricular contractility in rats
2006, Life SciencesCitation Excerpt :Reports have been shown that models of hypertension commonly produce a concentric cardiac hypertrophy by a pressure overload mechanism. Although resulting from several mechanisms it usually causes myocyte enlargement, collagen accumulation, changes in the activity and expression of myosin ATPase, shift of V1 to V3 myosin heavy chain (MHC) isoforms and changes in Ca2+ handling by reducing sarcoplasmic reticulum activity (Mercadier et al., 1981; Tanamura et al., 1993; Arai et al., 1996; Mill et al., 1998; Shorofsky et al., 1999; Swynghedauw, 1999). In consequence, the alterations in the mechanical properties of the myocardium together with the prolongation of contraction duration and depressed shortening velocity usually impair force development (Swynghedauw, 1999; Shorofsky et al., 1999).
Nifedipine represses ion channels, transporters and Ca<sup>2+</sup>-binding proteins in hearts of spontaneously hypertensive rats
2006, Toxicology and Applied PharmacologySpecific and sustained down-regulation of genes involved in fatty acid metabolism is not a hallmark of progression to cardiac failure in mice
2006, Journal of Molecular and Cellular CardiologyTranscription factor Sp1 regulates SERCA2 gene expression in pressure-overloaded hearts: A study using in vivo direct gene transfer into living myocardium
2003, Journal of Molecular and Cellular CardiologyLeft ventricular SERCA2a gene down-regulation does not parallel ANP gene up-regulation during post-MI remodelling in rats
2005, European Journal of Heart Failure
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Please address all correspondence to: Masashi Arai, Second Department of Internal Medicine, Gunma University School of Medicine, Showa-machi, Maebashi, Gunma 371, Japan.