Regular ArticleThe Role of Gi-proteins andβ-Adrenoceptors in the Age-related Decline of Contraction in Guinea-pig Ventricular Myocytes☆
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Inhibitory G-protein–mediated modulation of slow delayed rectifier potassium channels contributes to increased susceptibility to arrhythmogenesis in aging heart
2021, Heart RhythmCitation Excerpt :However, our results indicated that Gi expression showed no alterations at either mRNA or protein levels in aging heart. An earlier study demonstrated that Gi activity is significantly increased in aging guinea pig hearts.16 Accumulating evidence has proven that aging hearts have increased β2/β1 ratio and a putative bias of β2ARs toward coupling to Gi rather than to Gs, which results in upregulation of β2AR-Gi signaling.17
Exercise training affects age-induced changes in SOD and heat shock protein expression in rat heart
2006, Experimental GerontologyAge increases cardiac Gα<inf>i2</inf> expression, resulting in enhanced coupling to G protein-coupled receptors
2002, Journal of Biological ChemistryCitation Excerpt :Although decreases in AC activity with age could be due to decreased amounts of AC or its targets, the fact that PTX treatment restores β2AR- and glucagon receptor-stimulated AC signals in older hearts to the levels in younger hearts indicates that PTX-sensitive proteins are responsible for the decreased receptor-stimulated enzyme activity. PTX treatment in both guinea pig heart and rat bladder results in similar reversals of age-induced decreases in AC (20, 52). We conclude that elevated Gαi is the main cause of reduced AC activity in aged rat left ventricles.
The aging heart and exercise training
2002, Archives of Gerontology and GeriatricsCalcium cycling in the aged heart
1999, Asia Pacific Heart Journal
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Please address all correspondence to: S. E. Harding, Cardiac Medicine, National Heart and Lung Institute, Dovehouse Street, London SW3 6LY, UK.