Regular ArticleInhibition of Angiotensin-converting Enzyme Increases the Nitric Oxide Levels in Canine Ischemic Myocardium
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No altered blood pressure and serum markers of oxidative stress after a long time dietary fish oil in the genetically 9 month-old type-2 diabetes Zucker rat
2010, Prostaglandins Leukotrienes and Essential Fatty AcidsCitation Excerpt :Our results revealed an inverse relationship between ACE activity and NO levels. This should be related to the fact that inhibition of ACE is known to trigger an increase in NO levels, as previously reported in canine ischemic myocardium [42] and in bovine aortic endothelial cells [43]. Moreover, these results are consistent with the study of Takemoto et al., which showed long-term inhibition of NO production (by L-NAME) causes high ACE activity in heart and aorta [44].
Participation of kallikrein-kinin system in different pathologies
2008, International ImmunopharmacologyCitation Excerpt :Several studies have shown that kinins exert cardioprotective effects on myocardial infarct and heart failure, such as reduction of both left ventricular hypertrophy and progression of heart failure [19–22]. The protective effects of BK are mainly mediated by B2 receptor due to NO production by endothelial cells [23,24], induction of antiproliferative effects on fibroblasts [25,26] and antihypertrophic effects on cardiomyocytes [27,28]. Yao and coworkers [29] showed that kallikrein infusion in rats for 7 days after myocardial infarct induction improved cardiac function, normalized left ventricular wall thickness, and reduced macrophage infiltration in the infarcted heart.
Lovastatin induces the expression of bradykinin type 2 receptors in cultured human coronary artery endothelial cells
2007, Journal of Molecular and Cellular CardiologyCitation Excerpt :The cardioprotective effects are mainly mediated by a G-protein coupled receptor, the bradykinin type-2 receptor (BK-2R). Activation of BK-2Rs triggers the production and release of NO, EDHF and prostaglandins by the endothelial cells in the myocardium [4–7]. In addition, BK and Lys-BK mediate antiproliferative [8,9] and antihypertrophic [10,11] effects on fibroblasts and myocytes, respectively.
Recent advances in the understanding of the role of nitric oxide in cardiovascular homeostasis
2005, Pharmacology and TherapeuticsDown-regulation of cardioprotective bradykinin type-2 receptors in the left ventricle of patients with end-stage heart failure
2002, Journal of the American College of Cardiology
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Please address correspondence to: Masafumi Kitakaze, The First Department of Medicine, Osaka University School of Medicine, 2-2 Yamadaoka, Suita 565-0871, Japan.