Regular ArticleThrombospondin-1 Is Elevated with both Intimal Hyperplasia and Hypercholesterolemia☆
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Thrombospondin-1 in vascular development, vascular function, and vascular disease
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2023, Matrix BiologyFluvastatin inhibits intimal hyperplasia in wild-type but not Thbs1-null mice
2017, Journal of Surgical ResearchCitation Excerpt :TSP-1 normally has a low plasma concentration and is not part of the normal arterial architecture21; however, in pathologic states such as PAD, the plasma levels of TSP-1 become elevated.12 Evidence that TSP-1 is a regulator of the acute response to arterial injury and vascular remodeling is that TSP-1 is (1) immediately abundant at sites of platelet activation (TSP-1 constitutes 25% of protein released by α granules), (2) a major biosynthetic product of associated cells (e.g., fibroblasts, macrophages, endothelial cells, platelet-derived growth factor–stimulated VSMCs), and (3) expressed in the arterial wall containing atherosclerotic plaque, after acute arterial injury and in early IH lesions.3,21-26 Consistent with the present work, several prior studies have demonstrated a functional significance for TSP-1 in IH development after arterial injury using different TSP-1 blocking strategies.
Review: The role of thrombospondin-1 in cardiovascular health and pathology
2013, International Journal of Cardiology
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J. Lahav