Regular ArticleOpening of Potassium Channels Protects Mitochondrial Function from Calcium Overload☆,☆☆
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2009, Journal of Molecular and Cellular CardiologyCitation Excerpt :Thus although reports have demonstrated an ATP-sensitive K+ current in patch-clamped mitoplasts [178,179], the evidence for this being the end-effector of IPC is very indirect and certainly not conclusive. Nevertheless, the theory is that opening of mKATP during the IPC would depolarise the membrane slightly, but sufficiently to inhibit Ca2+ uptake through MCU [174]. Reducing [Ca2+]m would in turn reduce the likelihood of MPTP opening on reperfusion — and indeed reduced MPTP opening has been found in IPC of whole hearts [180].
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Presented at the 33rd Annual Meeting of the Association for Academic Surgery, Philadelphia, Pennsylvania, November 1999.
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This work was partially supported by NIH Grant RO 1-HL39208 (M.D.O.).
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To whom reprint requests should be addressed at University of Maryland Medical System, Department of Surgery, 22 South Greene St., Baltimore, MD 21201.