Regular Articlec-fos Antisense Oligonucleotide Specifically Attenuates Haloperidol-Induced Increases in Neurotensin/neuromedin N mRNA Expression in Rat Dorsal Striatum
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The role of endogenous neurotensin in psychostimulant-induced disruption of prepulse inhibition and locomotion
2012, Schizophrenia ResearchCitation Excerpt :APDs and stimulants induce c-fos mRNA and NT/NN mRNA expression in slightly different anatomical patterns (Merchant et al., 1994). However, the effects of both APDs and stimulants on the NT system are partially mediated by c-fos (Merchant, 1994). Blockade of c-fos mRNA expression prevented haloperidol NT/NN mRNA induction in the rat dorsolateral striatum, but not in the NAcc shell (Merchant et al., 1994).
Mesolimbic dopamine and cortico-accumbens glutamate afferents as major targets for the regulation of the ventral striato-pallidal GABA pathways by neurotensin peptides
2007, Brain Research ReviewsCitation Excerpt :Furthermore, central NT receptors upon activation can reinstate cocaine seeking in rodents (Lopak and Erb, 2005) giving further indications for a role of NT receptors also in the altered neuroplasticity that underlies development of cocaine addiction. To understand the NT receptor mechanisms involved it is important to underline that in contrast to the case after treatment with typical antipsychotic drugs, psychostimulants increase NT levels mainly in subpopulations of the striato-nigral GABA pathways (Merchant, 1994) regulated primarily by the D1 receptors. Unlike many D2 receptors (see above) D1 receptors are not antagonistically regulated by NTS1 and also mediate rewarding actions of psychostimulants.
Neurotensin: Dual roles in psychostimulant and antipsychotic drug responses
2003, Life SciencesCitation Excerpt :First, Fos mRNA is co-expressed in the majority (∼75%) of striatal neurons expressing NT mRNA in the dorsolateral striatum following APD treatment (Merchant and Miller, 1994). Second, APD activation of NT gene expression is attenuated by antisense inhibition of Fos expression and in Fos knockout mice (Merchant, 1994; Robertson et al., 1995; Shearman and Weaver, 1997). Finally, Fos activates the NT promoter through a consensus AP-1 binding site in tissue culture cells, suggesting that increased Fos expression could result in a similar activation of NT gene expression in vivo (Harrison et al., 1995).
Distribution, biochemistry and function of striatal adenosine A(2A) receptors
1999, Progress in Neurobiology