Regular ArticleThe α9/α10-Containing Nicotinic ACh Receptor Is Directly Modulated by Opioid Peptides, Endomorphin-1, and Dynorphin B, Proposed Efferent Cotransmitters in the Inner Ear
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2022, Hearing ResearchAtypical opioid receptors: unconventional biology and therapeutic opportunities
2022, Pharmacology and TherapeuticsCitation Excerpt :This highlights that they may contribute to nociception as well as the onset of a tolerant profile in a ligand-dependent manner. Importantly, a family of ion channels, the α9/α10-containing nicotinic acetylcholine receptors, were shown to be inhibited by opioid peptides in Xenopus oocytes (Lioudyno et al., 2002). It is therefore tempting to speculate that other ion channels are equally modulated by endogenous and/or exogenous opioids, independently of classical opioid receptors, however there are still few reports assessing such interaction.
6.34 - Synaptic and Pharmacological Organization of Efferent Influences on Hair Cells and Vestibular Afferent Fibers
2020, The Senses: A Comprehensive Reference: Volume 1-7, Second EditionDynorphin release by the lateral olivocochlear efferents may inhibit auditory nerve activity: A cochlear drug delivery study
2014, Neuroscience LettersCitation Excerpt :Based on the predicted concentrations calculated using a variety of biologically plausible assumptions in the models submitted to the Washington University Cochlear Fluids Simulator, the 5-mM (−)pentazocine solutions on the RWM of the guinea pig cochlea concentrations might be on the order of 150-μM at/near 16-kHz and 30-μM at/near 8-kHz, with minimal (<5-μM) diffusion reaching regions at/near 4-kHz, and closer to the apex. These concentrations better approximate the micromolar levels suggested by Lioudyno et al. [28], although the effects of (−)pentazocine may not be identical to those of endogenous dyn peptides. Threshold improved and evoked potential amplitude increased for 0–20 dB SL clicks after intravenous 8–20 mg/kg (−)pentazocine or U50488 [34,37], with no changes in amplitude at 40-dB SL [36].
The efferent medial olivocochlear-hair cell synapse
2012, Journal of Physiology Paris
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