Regular ArticleDistribution and Modulation of Histamine H3 Receptors in Basal Ganglia and Frontal Cortex of Healthy Controls and Patients with Parkinson's Disease
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2021, Handbook of Clinical NeurologyGenetic lack of histamine upregulates dopamine neurotransmission and alters rotational behavior but not levodopa-induced dyskinesia in a mouse model of Parkinson's disease
2020, Neuroscience LettersCitation Excerpt :Depolarization-stimulated [3H]dopamine release (Fig. 3B) was significantly increased in HDC KO animals (t(9) = 3.382, p = 0.0081), but neither half-maximal (0.5 μM) nor maximal (10 μM) amphetamine-induced [3H]dopamine release (Fig. 3C) differed between HDC KO and WT mice. The histaminergic and dopaminergic systems interact closely within the basal ganglia, and the histaminergic system could play a significant role in conditions of dopaminergic dysfunction such as Parkinson’s disease and levodopa-induced dyskinesia [3–7]. Here, the role of histamine in PD and LID was studied by investigating the consequences of a lack of endogenous histamine in conditions of dopaminergic denervation.
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