Regular ArticleTemporal Dynamics of Brain Tissue Nitric Oxide during Functional Forepaw Stimulation in Rats
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2022, Free Radical Biology and MedicineCitation Excerpt :Basal NO levels have been reported to lie in low nanomolar or even subnanomolar concentration ranges [12,13]. Stimulus-associated NO concentrations on the order of 100 nM are observed during brain activity [14], while NO levels released by activated immune and vascular cells can reach concentrations of around 1 μM [15,16]; but these elevated NO concentrations are highly transient [17], further complicating their detection. By comparison, typical molecular MRI probes are paramagnetic species that must usually be present at steady-state concentrations over 10 μM in order to produce noticeable effects.
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2021, Journal of Neuroscience MethodsNeurovascular-neuroenergetic coupling axis in the brain: master regulation by nitric oxide and consequences in aging and neurodegeneration
2017, Free Radical Biology and MedicineCitation Excerpt :Overcoming the technological challenge associated to the real time dynamic measure of •NO, Buerk and collaborators made a relevant contribution by firstly providing evidence for the temporal correlation of the •NO dynamics and CBF changes in the rat somatosensory cortex upon forepaw electrical stimulation, establishing that increases in •NO proceeded that of CBF. However, the authors failed to address the interdependency of the two events [45]. Following this line, and by complementing the simultaneous in vivo measurement of •NO dynamics and CBF with pharmacological approaches, we pinpointed •NO derived from nNOS as the direct mediator of neurovascular coupling in the hippocampus.
Non-uniform viscosity caused by red blood cell aggregation may affect NO concentration in the microvasculature
2017, Biocybernetics and Biomedical EngineeringCitation Excerpt :Endogenously-produced nitric oxide (NO) has important physiological effects in the vasculature, nervous systems and respiratory system [1,2].
Neurovascular coupling in hippocampus is mediated via diffusion by neuronal-derived nitric oxide
2014, Free Radical Biology and Medicine