BRIEF REPORTPosttraining Administration of Substance P and Its N-terminal Fragment Block the Amnestic Effects of Diazepam☆
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Cited by (14)
Dorsal periaqueductal gray post-stimulation freezing is counteracted by neurokinin-1 receptor antagonism in the central nucleus of the amygdala in rats
2015, Neurobiology of Learning and MemoryCitation Excerpt :The reduction of post-stimulation freezing by SPA injection into the CeA prevented the proaversive effects of electrical stimulation of the dPAG 24 h later in the EPM. Some evidence indicates that SP via NK1 receptors can have memory-promoting effects when administered into the CeA or systemically (Costa & Tomaz, 1998; Hasenohrl et al., 2000; Kertes, Laszlo, Berta, & Lenard, 2009b; Kertes et al., 2009a). Moreover, of all the areas in the central nervous system, the amygdala is most clearly implicated in evaluating the emotional meaning of incoming stimuli (LeDoux, 1986).
Neuropeptides in learning and memory
2013, NeuropeptidesCitation Excerpt :The authors explained these actions by the inflammatory effects of SP causing increased permeability of the blood–brain barrier, as well as activation of microglial cells and astrocytes. In addition, diazepam-induced amnestic effect can be blocked by SP administration (Costa and Tomaz, 1998). SP and NK1 receptor expression in the marginal division of the neostriatum is very high and the memory-promoting effect of SP, at least in this brain region, is NK1-mediated (Liu et al., 2011b).
Interference of ethanol and methylmercury in the developing central nervous system
2009, NeuroToxicologyModulation of anxiety in rats evaluated in the elevated T-maze: Evidence of the relationship between substance P and diazepam
2008, Behavioural Brain Research
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E. Costa
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This research was supported by CNPq (Grant 520316/94-0 to C.T.) and a CAPES Fellowship to J.C.C. Address reprint requests to Dr. Carlos Tomaz at the Laboratory of Neurobiology, University of Brası́lia, IBD/CFS, C.P. 04631, 70919-900 Brası́lia, DF, Brazil. Fax: (+55) 61 274 1251. E-mail:[email protected].