Review ArticleAdenosine-mediated Bronchoconstriction and Lung Inflammation in an Allergic Mouse Model
References (38)
- et al.
Adenosine inhibits and potentiates IgE-dependent histamine release from human lung mast cells by an A2-purinoceptor mediated mechanism
Biochem Pharmacol
(1984) - et al.
Evidence for A1 and A2 adenosine receptors in guinea-pig trachea
Life Sci
(1987) - et al.
Anti-inflammatory effects of low-density theophylline atopic asthma
Lancet
(1994) - et al.
Inhaled adenosine and guanosine on the airway resistance in normal and asthmatic subjects
Br J Clin Pharmacol
(1983) - et al.
Adenosine in bronchoalveolar lavage fluid in asthma
Am Rev Respir Dis
(1993) Release of adenosine from rat lung by antigen and compound 48/80
Acta Physiol Scand
(1981)- et al.
Airway effects of purine nucleosides and nucleotides and release with bronchial provocation in asthma
J Appl Physiol
(1986) - et al.
Adenosine-induced bronchoconstriction and contraction of airway smooth muscle from allergic rabbits with late-phase airway obstruction. Evidence for an inducible adenosine A1 receptor
J Pharmacol Exp Ther
(1994) - et al.
Adenosine receptor-mediated bronchoconstriction and bronchial hyperresponsiveness in allergic rabbit model
Am J Physiol
(1994) - et al.
A1 adenosine receptor-mediated Ins (1,4,5) P3 generation in allergic rabbit airway smooth muscle
Am J Physiol
(1998)
DNA antisense therapy for asthma in an animal model
Nature
Effect of exogenous adenosine on resistance, capillary permeability-surface area and flow in ischemic canine myocardium
J Pharmacol Exp Ther
Role of adenosine in adipose tissue circulation
Acta Physiol Scand
Effect of cromolyn on adenosine-induced airway microvascular leakage in sensitized rats
Eur Respir J
Differential regulation of human basophil and lung mast cell function by adenosine
J Pharmacol Exp Ther
Effects of adenosine on guinea pig pulmonary eosinophils
Inflamm
Bronchial challenge with adenosine causes the release of serum neutrophil chemotactic factor in asthma
Am Rev Respir Dis
Adenosine promotes neutrophil chemotaxis
J Exp Med
Adenosine-induced secretion in the canine trachea: modification by methylxanthines and adenosine derivatives
Br J Pharmacol
Cited by (40)
Extracellular metabolism of 3′,5′-cyclic AMP as a source of interstitial adenosine in the rat airways
2021, Biochemical PharmacologyHyperresponsiveness to adenosine in sensitized Wistar rats over-expressing A<inf>1</inf> receptor
2012, European Journal of PharmacologyCitation Excerpt :Results obtained from the functional studies showed that challenge of actively sensitized rats with aerosolized ovalbumin induced bronchial hyperreactivity, evidenced by an increased bronchoconstriction in response to all spasmogens used, that was not observed when sensitized rats were challenged with aerosolized saline. This finding is in accordance with previous experimental works performed on Brown Norway rats (Hannon et al., 2001) and on allergic mice (Fan and Mustafa, 2002) and demonstrates that, in Wistar rats, sensitization per sè does not cause bronchial hyperreactivity but allergen challenge is required to establish bronchial hyperreactivity, an important feature of allergic asthma. It is worth noting that this finding is also consistent with clinical observations about asthma; in fact, it must be considered that asthmatics undergo regular exposure to allergen.
Adenosine receptors and vascular inflammation
2011, Biochimica et Biophysica Acta - BiomembranesCitation Excerpt :ADA deficient mice demonstrate the presence of eosinophilia in the lungs, extensive mast cell degranulation and increased levels of serum IgE [23], indicating a strong correlation between chronic elevation of adenosine levels and increased lung inflammation. There is evidence that adenosine causes recruitment of inflammatory cells to the lung [24] and amplification of the inflammatory response [25]. In allergic mice, adenosine, among other inflammatory mediators from allergic lung and activated leukocytes, is released [16,26].
Airway hyperresponsiveness to adenosine 5'-monophosphate in feline chronic inflammatory lower airway disease
2011, Veterinary JournalCitation Excerpt :Cushley et al. (1983) first reported a concentration-dependent bronchoconstriction after inhalation of adenosine in asthmatic humans, but not in healthy volunteers. Similarly, in other species such as mice (Fan and Mustafa, 2002), Brown Norway rats (Hannon et al., 2001), guinea pigs (Thorne and Broadley, 1994) and rabbits (Ali et al., 1994), adenosine caused no or very weak bronchoconstrictor responses in healthy subjects. Adenosine’s ester AMP is as effective and much more water soluble (Mann et al., 1986).
Increased muscarinic receptor activity of airway smooth muscle isolated from a mouse model of allergic asthma
2010, Pulmonary Pharmacology and TherapeuticsCitation Excerpt :Adenosine also failed to produce a contractile response in trachea from O/V mice, i.e. sensitised but not OVA-challenged. This was surprising since sensitised and naive mice [15,43], sensitised guinea-pigs [44] and asthmatic patients [45] produce bronchoconstriction to NECA and adenosine in vivo. Passive or active sensitisation therefore favours a bronchoconstrictor response to adenosine in isolated trachea from guinea-pigs [46] but not mice.
Regadenoson: A New Myocardial Stress Agent
2009, Journal of the American College of CardiologyCitation Excerpt :Trochu et al. (17) further showed in an animal model the lack of A1response in contradistinction to a dose-dependent A2Aresponse. Regadenoson was also shown to have absent bronchoconstrictive response in control and allergen-sensitized mice (18). By design, regadenoson has a low affinity for the A2Aadenosine receptor.
- f1
Author for correspondence: S. Jamal Mustafa, Ph.D., Department of Pharmacology, Brody school of Medicine, East Carolina University, Greenville, NC 27858, USA. Tel: (252) 816–2736; Fax: (252) 816–3203; E-mail:[email protected]