Regular ArticleReceptor-Mediated Pathways That Modulate Calcium Channels☆
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Cited by (15)
Sense and sensibility in the regulation of voltage-gated Ca<sup>2+</sup> channels
2002, Trends in NeurosciencesVoltage-independent Inhibition of P/Q-type Ca<sup>2+</sup> Channels in Adrenal Chromaffin Cells via a Neuronal Ca<sup>2+</sup> Sensor-1-dependent Pathway Involves Src Family Tyrosine Kinase
2001, Journal of Biological ChemistryCitation Excerpt :Multiple pathways exist for the regulation of neuronal voltage-gated Ca2+ channels. One inhibitory pathway involving GPCRs (1-3) is the so-called voltage-dependent pathway (4, 5). Occupation of various GPCRs leads to release of βγ subunits that directly interact with (41-43) and inhibit the α1subunits of N- and P/Q-type Ca2+ channels (2, 44).
Neuronal Ca<sup>2+</sup> sensor-1/frequenin functions in an autocrine pathway regulating Ca<sup>2+</sup> channels in bovine adrenal chromaffin cells
2000, Journal of Biological ChemistryCitation Excerpt :The autocrine inhibition of Ca2+ channels in chromaffin cells can be overcome, but only partially, by prior strong depolarization (facilitation) suggesting the presence of both voltage-dependent and -independent mechanisms for channel inhibition (27, 28). Two distinct receptor-dependent pathways for channel inhibition that differ in their reversibility by prior depolarization have been described for various neuronal cell types (33-37). To test which type of pathway was blocked by NCS-1(E120Q), Ca2+ currents were examined before and after a 50-ms prepulse to +90 mV.
Selective coupling of G protein βγ complexes to inhibition of Ca<sup>2+</sup> channels
2000, Journal of Biological ChemistryCloning and functional expression of novel N-type Ca<sup>2+</sup> channel variants
1999, Journal of Biological Chemistry
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R. IyengarL. Birnbaumer
- 1
To whom correspondence should be addressed. Fax: (617) 636-8412. E-mail: [email protected].