Abstract
The heat/capsaicin sensitization and intradermal capsaicin injection models are safe and noninvasive paradigms to generate stable, long-lasting, and reproducible injury capable of producing an area of both primary and secondary hyperalgesia. Risk of skin injury is substantially reduced since lower levels of thermal and chemical irritation produce long-lasting cutaneous hyperalgesia. Rekindling sustains central sensitization by providing peripheral nociceptive input. The intradermal capsaicin model has been widely used to test analgesic efficacy for a wide range of analgesics. Unlike the heat/capsaicin sensitization model, intradermal capsaicin results in a brief painful stimulus followed by a long lasting area of secondary hyperalgesia. The intradermal injection of capsaicin results in a transient, intense stinging sensation at the site of injection (e.g. heat allodynia) followed by a persistent area of secondary tactile allodynia.
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Petersen KL, Jones B, Segredo V, Dahl J, Rowbotham MC (2001) Effect of remifentanil on pain and secondary hyperalgesia associated with the heat-capsaicin sensitization model in healthy volunteers. Anesthesiology 94(1):15–20
Dirks J, Petersen KL, Dahl JB (2003) The heat/capsaicin sensitization model: a methodologic study. J Pain 4(3):122–128
Petersen KL, Maloney A, Hoke F, Dahl JB, Rowbotham MC (2003) A randomized study of the effect of oral lamotrigine and hydromorphone on pain and hyperalgesia following heat/capsaicin sensitization. J Pain 4(7):400–406
Frymoyera AR, Rowbothama MC, Petersen KL (2006) Placebo-controlled comparison of a morphine/dextromethorphan combination with morphine on experimental pain and hyperalgesia in healthy volunteers. J Pain 8(1):19–25
LaMotte RH et al (1991) Neurogenic hyperalgesia: psychophysical studies of underlying mechanisms. J Neurophysiol 66:190–211
LaMotte RH, Lundberg LE, Torebjork E (1992) Pain, hyperalgesia and activity in nociceptive C units in humans after intradermal injection of capsaicin. J Physiol 448:749–764
Wallace MS et al (2002) Concentration-effect relationships for intravenous alfentanil and ketamine infusions in human volunteers: effects upon acute thresholds and capsaicin-evoked hyperpathia. J Clin Pharmacol 42:70–80
Wallace MS et al (1997) Concentration-effect relations for intravenous lidocaine infusions in human volunteers: effect on acute sensory thresholds and capsaicin-evoked hyperpathia. Anesthesiology 86:1262–1272
Wallace MS, Grubbs D (2002) Effects of oral desipramine on capsaicin induced hyperalgesia. Anesth Analg 95:973–978
Ando K et al (2000) Neurosensory finding after oral mexiletine in healthy volunteers. Reg Anesth Pain Med 25:468–474
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Modir, J.G., Wallace, M.S. (2010). Human Experimental Pain Models 3: Heat/Capsaicin Sensitization and Intradermal Capsaicin Models. In: Szallasi, A. (eds) Analgesia. Methods in Molecular Biology, vol 617. Humana Press, Totowa, NJ. https://doi.org/10.1007/978-1-60327-323-7_14
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DOI: https://doi.org/10.1007/978-1-60327-323-7_14
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Publisher Name: Humana Press, Totowa, NJ
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