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Psychiatric Disorders pp 243–256Cite as

Modeling Nicotine Addiction in Rats

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Part of the book series: Methods in Molecular Biology ((MIMB,volume 829))

Abstract

Among the human population, 15% of drug users develop a pathological drug addiction. This figure increases substantially with nicotine, whereby more than 30% of those who try smoking develop a nicotine addiction. Drug addiction is characterized by compulsive drug-seeking and drug-taking behaviors (craving), and loss of control over intake despite impairment in health, social, and occupational functions. This behavior can be accurately modeled in the rat using an intravenous self-administration (IVSA) paradigm. Initial attempts at establishing nicotine self-administration had been problematic, yet in recent times increasingly reliable models of nicotine self-administration have been developed. The present article reviews different characteristics of the nicotine IVSA model that has been developed to examine nicotine reinforcing and motivational properties in rats.

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Author information

Authors and Affiliations

  1. CNRS UMR 5287, “Neuropsychopharmacology of Addiction” Group, University of Bordeaux, Bordeaux, France

    Stephanie Caille, Luis Stinus & Martine Cador

  2. Neuropharmacology Laboratory, School of Psychology, The University of New South Wales, Sydney, NSW, Australia

    Kelly Clemens

Authors
  1. Stephanie Caille
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  2. Kelly Clemens
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  3. Luis Stinus
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  4. Martine Cador
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Corresponding author

Correspondence to Stephanie Caille .

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Editors and Affiliations

  1. McKnight Brain Institute, Department of Psychiatry, University of Florida, S. Newell Dr. 100, Gainesville, 32610, Florida, USA

    Firas H. Kobeissy

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Caille, S., Clemens, K., Stinus, L., Cador, M. (2012). Modeling Nicotine Addiction in Rats. In: Kobeissy, F. (eds) Psychiatric Disorders. Methods in Molecular Biology, vol 829. Humana Press. https://doi.org/10.1007/978-1-61779-458-2_15

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  • DOI: https://doi.org/10.1007/978-1-61779-458-2_15

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