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Regulation of Alternative Splicing pp 187–216Cite as

Alternative Pre-mRNA Splicing and Neuronal Function

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Part of the book series: Progress in Molecular and Subcellular Biology ((PMSB,volume 31))

Abstract

The protein output of a gene is often regulated by splicing the primary RNA transcript into multiple mRNAs that differ in their coding exon sequences. These alternative splicing patterns are found in all kinds of genes and tissues. However, in the nervous system, proteins involved in two processes show particularly high levels of molecular diversity created by alternative splicing. These are proteins that determine the formation of neuronal connections during development and proteins that mediate cell excitation. Although some systems of splicing are highly complex, work on simpler model systems has started to identify the molecular components that determine these splicing switches. This review describes how alternative splicing is central to the control of neuronal function, and what is currently known about its mechanisms of regulation. How errors in splicing might contribute to diseases of the nervous system is also discussed.

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  1. Howard Hughes Medical Institute, University of California, Los Angeles, MRL 5-748, 675 Charles E. Young Dr. South, Los Angeles, California, 90095, USA

    D. L. Black

  2. Howard Hughes Medical Institute and Department of Biological Sciences, University of Pittsburgh, 4249 Fifth Avenue, Pittsburgh, Pennsylvania, 15260, USA

    P. J. Grabowski

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  1. Institute of Molecular Genetics of Montpellier, CNRS, 1919 Route de Mende, BP 5051, 34293, Montpellier Cedex 05, France

    Philippe Jeanteur

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Black, D.L., Grabowski, P.J. (2003). Alternative Pre-mRNA Splicing and Neuronal Function. In: Jeanteur, P. (eds) Regulation of Alternative Splicing. Progress in Molecular and Subcellular Biology, vol 31. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-662-09728-1_7

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