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How Positive and Negative Expectations Shape the Experience of Visceral Pain

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Book cover Placebo

Part of the book series: Handbook of Experimental Pharmacology ((HEP,volume 225))

Abstract

Knowledge from placebo and nocebo research aimed at elucidating the role of treatment expectations and learning experiences in shaping the response to visceral pain fills an important research gap. First, chronic abdominal pain, such as in irritable bowel syndrome (IBS), is highly prevalent, with detrimental individual and socioeconomic impact and limited effective treatment options. At the same time, IBS patients show high placebo response rates in clinical trials and benefit from placebo interventions. Second, psychological factors including emotions and cognitions in the context of visceral pain have been implicated in the pathophysiology of IBS and other conditions characterized by medically unexplained somatic symptoms. Hence, the study of nocebo and placebo effects in visceral pain constitutes a model to assess the contribution of psychological factors. Herein, the clinical relevance of visceral pain is introduced with a focus on IBS as a bio-psycho-social disorder, followed by a review of existing clinical and experimental work on placebo and nocebo effects in IBS and in clinically relevant visceral pain models. Finally, emerging research trends are highlighted along with an outlook regarding goals for ongoing and future research.

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References

  • Agarwal N, Spiegel BM (2011) The effect of irritable bowel syndrome on health-related quality of life and health care expenditures. Gastroenterol Clin North Am 40:11–19

    PubMed  Google Scholar 

  • Aslaksen PM, Myrbakk IN, Hoifodt RS, Flaten MA (2007) The effect of experimenter gender on autonomic and subjective responses to pain stimuli. Pain 129:260–268

    PubMed  Google Scholar 

  • Aslaksen PM, Bystad M, Vambheim SM, Flaten MA (2011) Gender differences in placebo analgesia: event-related potentials and emotional modulation. Psychosom Med 73:193–199

    PubMed  CAS  Google Scholar 

  • Averbuch M, Katzper M (2001) Gender and the placebo analgesic effect in acute pain. Clin Pharmacol Ther 70:287–291

    PubMed  CAS  Google Scholar 

  • Aziz Q, Thompson DG, Ng VW, Hamdy S, Sarkar S, Brammer MJ, Bullmore ET, Hobson A, Tracey I, Gregory L, Simmons A, Williams SC (2000) Cortical processing of human somatic and visceral sensation. J Neurosci 20:2657–2663

    PubMed  CAS  Google Scholar 

  • Benedetti F (1996) The opposite effects of the opiate antagonist naloxone and the cholecystokinin antagonist proglumide on placebo analgesia. Pain 64:535–543

    PubMed  CAS  Google Scholar 

  • Benedetti F, Amanzio M, Casadio C, Oliaro A, Maggi G (1997) Blockade of nocebo hyperalgesia by the cholecystokinin antagonist proglumide. Pain 71:135–140

    PubMed  CAS  Google Scholar 

  • Benedetti F, Mayberg HS, Wager TD, Stohler CS, Zubieta JK (2005) Neurobiological mechanisms of the placebo effect. J Neurosci 25:10390–10402

    PubMed  CAS  Google Scholar 

  • Benedetti F, Amanzio M, Vighetti S, Asteggiano G (2006) The biochemical and neuroendocrine bases of the hyperalgesic nocebo effect. J Neurosci 26:12014–12022

    PubMed  CAS  Google Scholar 

  • Benson S, Kotsis V, Rosenberger C, Bingel U, Forsting M, Schedlowski M, Gizewski ER, Elsenbruch S (2012) Behavioural and neural correlates of visceral pain sensitivity in healthy men and women: does sex matter? Eur J Pain 16:349–358

    PubMed  CAS  Google Scholar 

  • Benson S, Kattoor J, Kullmann JS, Hofmann S, Engler H, Forsting M, Gizewski ER, Elsenbruch S (2014) Towards understanding sex differences in visceral pain: enhanced reactivation of classically-conditioned fear in healthy women. Neurobiol Learn Mem 109:113–121

    PubMed  Google Scholar 

  • Berman S, Munakata J, Naliboff BD, Chang L, Mandelkern M, Silverman D, Kovalik E, Mayer EA (2000) Gender differences in regional brain response to visceral pressure in IBS patients. Eur J Pain 4:157–172

    PubMed  CAS  Google Scholar 

  • Berman SM, Naliboff BD, Suyenobu B, Labus JS, Stains J, Bueller JA, Ruby K, Mayer EA (2006) Sex differences in regional brain response to aversive pelvic visceral stimuli. Am J Physiol Regul Integr Comp Physiol 291:R268–R276

    PubMed  CAS  Google Scholar 

  • Bingel U, Wanigasekera V, Wiech K, Ni Mhuircheartaigh R, Lee MC, Ploner M, Tracey I (2011) The effect of treatment expectation on drug efficacy: imaging the analgesic benefit of the opioid remifentanil. Sci Transl Med 3:70ra14

    PubMed  Google Scholar 

  • Bjorkedal E, Flaten MA (2012) Expectations of increased and decreased pain explain the effect of conditioned pain modulation in females. J Pain Res 5:289–300

    PubMed  PubMed Central  Google Scholar 

  • Bonaz BL, Bernstein CN (2013) Brain-gut interactions in inflammatory bowel disease. Gastroenterology 144:36–49

    PubMed  Google Scholar 

  • Bradford K, Shih W, Videlock EJ, Presson AP, Naliboff BD, Mayer EA, Chang L (2012) Association between early adverse life events and irritable bowel syndrome. Clin Gastroenterol Hepatol 10:385–390

    PubMed  PubMed Central  Google Scholar 

  • Butcher BE, Carmody JJ (2012) Sex differences in analgesic response to ibuprofen are influenced by expectancy: a randomized, crossover, balanced placebo-designed study. Eur J Pain 16:1005–1013

    PubMed  CAS  Google Scholar 

  • Chang L, Mayer EA, Labus JS, Schmulson M, Lee OY, Olivas TI, Stains J, Naliboff BD (2006a) Effect of sex on perception of rectosigmoid stimuli in irritable bowel syndrome. Am J Physiol Regul Integr Comp Physiol 291:R277–R284

    PubMed  CAS  Google Scholar 

  • Chang L, Toner BB, Fukudo S, Guthrie E, Locke GR, Norton NJ, Sperber AD (2006b) Gender, age, society, culture, and the patient’s perspective in the functional gastrointestinal disorders. Gastroenterology 130:1435–1446

    PubMed  Google Scholar 

  • Choung RS, Locke GR III (2011) Epidemiology of IBS. Gastroenterol Clin North Am 40:1–10

    PubMed  Google Scholar 

  • Colloca L, Miller FG (2011) The nocebo effect and its relevance for clinical practice. Psychosom Med 73:598–603

    PubMed  PubMed Central  Google Scholar 

  • Colloca L, Sigaudo M, Benedetti F (2008) The role of learning in nocebo and placebo effects. Pain 136:211–218

    PubMed  CAS  Google Scholar 

  • Colloca L, Petrovic P, Wager TD, Ingvar M, Benedetti F (2010) How the number of learning trials affects placebo and nocebo responses. Pain 151:430–439

    PubMed  PubMed Central  Google Scholar 

  • Compton P, Charuvastra VC, Ling W (2003) Effect of oral ketorolac and gender on human cold pressor pain tolerance. Clin Exp Pharmacol Physiol 30:759–763

    PubMed  CAS  Google Scholar 

  • Craggs JG, Price DD, Verne GN, Perlstein WM, Robinson MM (2007) Functional brain interactions that serve cognitive-affective processing during pain and placebo analgesia. NeuroImage 38:720–729

    PubMed  PubMed Central  Google Scholar 

  • Craggs JG, Price DD, Perlstein WM, Verne GN, Robinson ME (2008) The dynamic mechanisms of placebo induced analgesia: evidence of sustained and transient regional involvement. Pain 139:660–669

    PubMed  PubMed Central  Google Scholar 

  • Craig AD (2003) Interoception: the sense of the physiological condition of the body. Curr Opin Neurobiol 13:500–505

    PubMed  CAS  Google Scholar 

  • De Peuter S, Van Diest I, Vansteenwegen D, Van denBergh O, Vlaeyen JW (2011) Understanding fear of pain in chronic pain: interoceptive fear conditioning as a novel approach. Eur J Pain 15:889–894

    PubMed  Google Scholar 

  • Dorn SD, Kaptchuk TJ, Park JB, Nguyen LT, Canenguez K, Nam BH, Woods KB, Conboy LA, Stason WB, Lembo AJ (2007) A meta-analysis of the placebo response in complementary and alternative medicine trials of irritable bowel syndrome. Neurogastroenterol Motil 19:630–637

    PubMed  CAS  Google Scholar 

  • Dunckley P, Wise RG, Aziz Q, Painter D, Brooks J, Tracey I, Chang L (2005a) Cortical processing of visceral and somatic stimulation: differentiating pain intensity from unpleasantness. Neuroscience 133:533–542

    PubMed  CAS  Google Scholar 

  • Dunckley P, Wise RG, Fairhurst M, Hobden P, Aziz Q, Chang L, Tracey I (2005b) A comparison of visceral and somatic pain processing in the human brainstem using functional magnetic resonance imaging. J Neurosci 25:7333–7341

    PubMed  CAS  Google Scholar 

  • Dunckley P, Aziz Q, Wise RG, Brooks J, Tracey I, Chang L (2007) Attentional modulation of visceral and somatic pain. Neurogastroenterol Motil 19:569–577

    PubMed  CAS  Google Scholar 

  • Eickhoff SB, Lotze M, Wietek B, Amunts K, Enck P, Zilles K (2006) Segregation of visceral and somatosensory afferents: an fMRI and cytoarchitectonic mapping study. NeuroImage 31:1004–1014

    PubMed  Google Scholar 

  • Eippert F, Bingel U, Schoell ED, Yacubian J, Klinger R, Lorenz J, Büchel C (2009) Activation of the opioidergic descending pain control system underlies placebo analgesia. Neuron 63:533–543

    PubMed  CAS  Google Scholar 

  • Elsenbruch S (2011) Abdominal pain in irritable bowel syndrome: a review of putative psychological, neural and neuro-immune mechanisms. Brain Behav Immun 25:386–394

    PubMed  CAS  Google Scholar 

  • Elsenbruch S, Rosenberger C, Bingel U, Forsting M, Schedlowski M, Gizewski ER (2010) Patients with irritable bowel syndrome have altered emotional modulation of neural responses to visceral stimuli. Gastroenterology 139:1310–1319

    PubMed  Google Scholar 

  • Elsenbruch S, Kotsis V, Benson S, Rosenberger C, Reidick D, Schedlowski M, Bingel U, Theysohn N, Forsting M, Gizewski ER (2012a) Neural mechanisms mediating the effects of expectation in visceral placebo analgesia: an fMRI study in healthy placebo responders and nonresponders. Pain 153:382–390

    PubMed  Google Scholar 

  • Elsenbruch S, Schmid J, Basler M, Cesko E, Schedlowski M, Benson S (2012b) How positive and negative expectations shape the experience of visceral pain: an experimental pilot study in healthy women. Neurogastroenterol Motil 24:914–e460

    PubMed  CAS  Google Scholar 

  • Enck P, Benedetti F, Schedlowski M (2008) New insights into the placebo and nocebo responses. Neuron 59:195–206

    PubMed  CAS  Google Scholar 

  • Enck P, Junne F, Klosterhalfen S, Zipfel S, Martens U (2010) Therapy options in irritable bowel syndrome. Eur J Gastroenterol Hepatol 22:1402–1411

    PubMed  CAS  Google Scholar 

  • Enck P, Horing B, Weimer K, Klosterhalfen S (2012) Placebo responses and placebo effects in functional bowel disorders. Eur J Gastroenterol Hepatol 24:1–8

    PubMed  Google Scholar 

  • Enck P, Bingel U, Schedlowski M, Rief W (2013) The placebo response in medicine: minimize, maximize or personalize? Nat Rev Drug Discov 12:191–204

    PubMed  CAS  Google Scholar 

  • Fillingim RB, King CD, Ribeiro-Dasilva MC, Rahim-Williams B, Riley JL (2009) Sex, gender, and pain: a review of recent clinical and experimental findings. J Pain 10:447–485

    PubMed  PubMed Central  Google Scholar 

  • Finniss DG, Kaptchuk TJ, Miller F, Benedetti F (2010) Biological, clinical, and ethical advances of placebo effects. Lancet 375:686–695

    PubMed  PubMed Central  Google Scholar 

  • Flaten MA, Aslaksen PM, Finset A, Simonsen T, Johansen O (2006) Cognitive and emotional factors in placebo analgesia. J Psychosom Res 61:81–89

    PubMed  Google Scholar 

  • Flaten MA, Aslaksen PM, Lyby PS, Bjorkedal E (2011) The relation of emotions to placebo responses. Philos Trans R Soc Lond B Biol Sci 366:1818–1827

    PubMed  PubMed Central  Google Scholar 

  • Folks DG (2004) The interface of psychiatry and irritable bowel syndrome. Curr Psychiatry Rep 6:210–215

    PubMed  Google Scholar 

  • Ford AC, Moayyedi P (2010) Meta-analysis: factors affecting placebo response rate in the irritable bowel syndrome. Aliment Pharmacol Ther 32:144–158

    PubMed  CAS  Google Scholar 

  • Franconi F, Campesi I, Occhioni S, Antonini P, Murphy MF (2012) Sex and gender in adverse drug events, addiction, and placebo. Handb Exp Pharmacol 107–126

    Google Scholar 

  • Frissora CL, Koch KL (2005) Symptom overlap and comorbidity of irritable bowel syndrome with other conditions. Curr Gastroenterol Rep 7:264–271

    PubMed  Google Scholar 

  • Gijsbers K, Nicholson F (2005) Experimental pain thresholds influenced by sex of experimenter. Percept Mot Skills 101:803–807

    PubMed  CAS  Google Scholar 

  • Gramsch C, Kattoor J, Icenhour A, Forsting M, Schedlowski M, Gizewski ER, Elsenbruch S (2014) Learning and remembering pain-related fear: neural mechanisms mediating rapid differential conditioning, extinction and memory retrieval processes in human visceral pain. Neurobiol Learn Mem (in revision)

    Google Scholar 

  • Hall KT, Lembo AJ, Kirsch I, Ziogas DC, Douaiher J, Jensen KB, Conboy LA, Kelley JM, Kokkotou E, Kaptchuk TJ (2012) Catechol-O-methyltransferase val158met polymorphism predicts placebo effect in irritable bowel syndrome. PLoS ONE 7:e48135

    PubMed  CAS  PubMed Central  Google Scholar 

  • Horing B, Kugel H, Brenner V, Zipfel S, Enck P (2013) Perception and pain thresholds for cutaneous heat and cold, and rectal distension: associations and disassociations. Neurogastroenterol Motil 25:e791–e802

    PubMed  CAS  Google Scholar 

  • Jensen KB, Kaptchuk TJ, Kirsch I, Raicek J, Lindstrom KM, Berna C, Gollub RL, Ingvar M, Kong J (2012) Nonconscious activation of placebo and nocebo pain responses. Proc Natl Acad Sci USA 109:15959–15964

    PubMed  CAS  PubMed Central  Google Scholar 

  • Johansen O, Brox J, Flaten MA (2003) Placebo and nocebo responses, cortisol, and circulating beta-endorphin. Psychosom Med 65:786–790

    PubMed  CAS  Google Scholar 

  • Kaptchuk TJ, Kelley JM, Conboy LA, Davis RB, Kerr CE, Jacobson EE, Kirsch I, Schyner RN, Nam BH, Nguyen LT, Park M, Rivers AL, McManus C, Kokkotou E, Drossman DA, Goldman P, Lembo AJ (2008) Components of placebo effect: randomised controlled trial in patients with irritable bowel syndrome. BMJ 336:999–1003

    PubMed  PubMed Central  Google Scholar 

  • Kaptchuk TJ, Friedlander E, Kelley JM, Sanchez MN, Kokkotou E, Singer JP, Kowalczykowski M, Miller FG, Kirsch I, Lembo AJ (2010) Placebos without deception: a randomized controlled trial in irritable bowel syndrome. PLoS ONE 5:e15591

    PubMed  CAS  PubMed Central  Google Scholar 

  • Kattoor J, Gizewski ER, Kotsis V, Benson S, Gramsch C, Theysohn N, Maderwald S, Forsting M, Schedlowski M, Elsenbruch S (2013) Fear conditioning in an abdominal pain model: neural responses during associative learning and extinction in healthy subjects. PLoS ONE 8:e51149

    PubMed  CAS  PubMed Central  Google Scholar 

  • Kattoor J, Thurling M, Gizewski ER, Forsting M, Timmann D, Elsenbruch S (2014) Cerebellar contributions to different phases of visceral aversive extinction learning. Cerebellum 13:1–8

    PubMed  Google Scholar 

  • Kelley JM, Lembo AJ, Ablon JS, Villanueva JJ, Conboy LA, Levy R, Marci CD, Kerr CE, Kirsch I, Jacobson EE, Riess H, Kaptchuk TJ (2009) Patient and practitioner influences on the placebo effect in irritable bowel syndrome. Psychosom Med 71:789–797

    PubMed  PubMed Central  Google Scholar 

  • Kern MK, Jaradeh S, Arndorfer RC, Jesmanowicz A, Hyde J, Shaker R (2001) Gender differences in cortical representation of rectal distension in healthy humans. Am J Physiol Gastrointest Liver Physiol 281:G1512–G1523

    PubMed  CAS  Google Scholar 

  • Kim HS, Rhee PL, Park J, Lee JH, Kim YH, Kim JJ, Rhee JC (2006) Gender-related differences in visceral perception in health and irritable bowel syndrome. J Gastroenterol Hepatol 21:468–473

    PubMed  Google Scholar 

  • Klosterhalfen S, Kellermann S, Braun S, Kowalski A, Schrauth M, Zipfel S, Enck P (2009) Gender and the nocebo response following conditioning and expectancy. J Psychosom Res 66:323–328

    PubMed  Google Scholar 

  • Kokkotou E, Conboy LA, Ziogas DC, Quilty MT, Kelley JM, Davis RB, Lembo AJ, Kaptchuk TJ (2010) Serum correlates of the placebo effect in irritable bowel syndrome. Neurogastroenterol Motil 22:285–e81

    PubMed  CAS  PubMed Central  Google Scholar 

  • Kong J, Gollub RL, Polich G, Kirsch I, Laviolette P, Vangel M, Rosen B, Kaptchuk TJ (2008) A functional magnetic resonance imaging study on the neural mechanisms of hyperalgesic nocebo effect. J Neurosci 28:13354–13362

    PubMed  CAS  PubMed Central  Google Scholar 

  • Kotsis V, Benson S, Bingel U, Forsting M, Schedlowski M, Gizewski ER, Elsenbruch S (2012) Perceived treatment group affects behavioral and neural responses to visceral pain in a deceptive placebo study. Neurogastroenterol Motil 24:935–e462

    PubMed  CAS  Google Scholar 

  • Labus JS, Naliboff BN, Fallon J, Berman SM, Suyenobu B, Bueller JA, Mandelkern M, Mayer EA (2008) Sex differences in brain activity during aversive visceral stimulation and its expectation in patients with chronic abdominal pain: a network analysis. NeuroImage 41:1032–1043

    PubMed  CAS  PubMed Central  Google Scholar 

  • Lee HF, Hsieh JC, Lu CL, Yeh TC, Tu CH, Cheng CM, Niddam DM, Lin HC, Lee FY, Chang FY (2012) Enhanced affect/cognition-related brain responses during visceral placebo analgesia in irritable bowel syndrome patients. Pain 153:1301–1310

    PubMed  Google Scholar 

  • Lieberman MD, Jarcho JM, Berman S, Naliboff BD, Suyenobu BY, Mandelkern M, Mayer EA (2004) The neural correlates of placebo effects: a disruption account. NeuroImage 22:447–455

    PubMed  Google Scholar 

  • Linnman C, Rougemont-Bucking A, Beucke JC, Zeffiro TA, Milad MR (2011) Unconditioned responses and functional fear networks in human classical conditioning. Behav Brain Res 221:237–245

    PubMed  PubMed Central  Google Scholar 

  • Lu CL, Chang FY (2011) Placebo effect in patients with irritable bowel syndrome. J Gastroenterol Hepatol 26(Suppl 3):116–118

    PubMed  Google Scholar 

  • Lu HC, Hsieh JC, Lu CL, Niddam DM, Wu YT, Yeh TC, Cheng CM, Chang FY, Lee SD (2010) Neuronal correlates in the modulation of placebo analgesia in experimentally-induced esophageal pain: a 3 T-fMRI study. Pain 148:75–83

    PubMed  Google Scholar 

  • Lyby PS, Aslaksen PM, Flaten MA (2011) Variability in placebo analgesia and the role of fear of pain–an ERP study. Pain 152:2405–2412

    PubMed  Google Scholar 

  • Lyby PS, Forsberg JT, Asli O, Flaten MA (2012) Induced fear reduces the effectiveness of a placebo intervention on pain. Pain 153:1114–1121

    PubMed  Google Scholar 

  • Maxion-Bergemann S, Thielecke F, Abel F, Bergemann R (2006) Costs of irritable bowel syndrome in the UK and US. Pharmacoeconomics 24:21–37

    PubMed  Google Scholar 

  • Mayer EA, Berman S, Chang L, Naliboff BD (2004) Sex-based differences in gastrointestinal pain. Eur J Pain 8:451–463

    PubMed  Google Scholar 

  • Mertz H, Naliboff B, Munakata J, Niazi N, Mayer EA (1995) Altered rectal perception is a biological marker of patients with irritable bowel syndrome. Gastroenterology 109:40–52

    PubMed  CAS  Google Scholar 

  • Milad MR, Quirk GJ (2012) Fear extinction as a model for translational neuroscience: ten years of progress. Annu Rev Psychol 63:129–151

    PubMed  Google Scholar 

  • Mogil JS, Bailey AL (2010) Sex and gender differences in pain and analgesia. Prog Brain Res 186:141–157

    PubMed  Google Scholar 

  • Naliboff BD, Berman S, Chang L, Derbyshire SW, Suyenobu B, Vogt BA, Mandelkern M, Mayer EA (2003) Sex-related differences in IBS patients: central processing of visceral stimuli. Gastroenterology 124:1738–1747

    PubMed  Google Scholar 

  • Nozu T, Kudaira M, Kitamori S, Uehara A (2006) Repetitive rectal painful distention induces rectal hypersensitivity in patients with irritable bowel syndrome. J Gastroenterol 41:217–222

    PubMed  Google Scholar 

  • Palsson OS, Drossman DA (2005) Psychiatric and psychological dysfunction in irritable bowel syndrome and the role of psychological treatments. Gastroenterol Clin North Am 34:281–303

    PubMed  Google Scholar 

  • Patel SM, Stason WB, Legedza A, Ock SM, Kaptchuk TJ, Conboy L, Canenguez K, Park JK, Kelly E, Jacobson E, Kerr CE, Lembo AJ (2005) The placebo effect in irritable bowel syndrome trials: a meta-analysis. Neurogastroenterol Motil 17:332–340

    PubMed  CAS  Google Scholar 

  • Petrovic P, Kalso E, Petersson KM, Ingvar M (2002) Placebo and opioid analgesia– imaging a shared neuronal network. Science 295:1737–1740

    PubMed  CAS  Google Scholar 

  • Petrovic P, Dietrich T, Fransson P, Andersson J, Carlsson K, Ingvar M (2005) Placebo in emotional processing–induced expectations of anxiety relief activate a generalized modulatory network. Neuron 46:957–969

    PubMed  CAS  Google Scholar 

  • Price DD, Craggs J, Verne GN, Perlstein WM, Robinson ME (2007) Placebo analgesia is accompanied by large reductions in pain-related brain activity in irritable bowel syndrome patients. Pain 127:63–72

    PubMed  Google Scholar 

  • Price DD, Finniss DG, Benedetti F (2008) A comprehensive review of the placebo effect: recent advances and current thought. Annu Rev Psychol 59:565–590

    PubMed  Google Scholar 

  • Price DD, Craggs JG, Zhou Q, Verne GN, Perlstein WM, Robinson ME (2009) Widespread hyperalgesia in irritable bowel syndrome is dynamically maintained by tonic visceral impulse input and placebo/nocebo factors: evidence from human psychophysics, animal models, and neuroimaging. NeuroImage 47:995–1001

    PubMed  PubMed Central  Google Scholar 

  • Rief W, Bingel U, Schedlowski M, Enck P (2011) Mechanisms involved in placebo and nocebo responses and implications for drug trials. Clin Pharmacol Ther 90:722–726

    PubMed  CAS  Google Scholar 

  • Schmid J, Theysohn N, Gass F, Benson S, Gramsch C, Forsting M, Gizewski ER, Elsenbruch S (2013) Neural mechanisms mediating positive and negative treatment expectations in visceral pain: a functional magnetic resonance imaging study on placebo and nocebo effects in healthy volunteers. Pain 154:2372–2380

    PubMed  Google Scholar 

  • Schmid J, Langhorst J, Gass F, Theysohn N, Benson S, Engler H, Gizewski ER, Forsting M, Elsenbruch S (2014) Placebo analgesia in patients with functional and organic abdominal pain: a fMRI study in irritable bowel syndrome, ulcerative colitis and healthy volunteers. Gut (in press)

    Google Scholar 

  • Scott DJ, Stohler CS, Egnatuk CM, Wang H, Koeppe RA, Zubieta JK (2008) Placebo and nocebo effects are defined by opposite opioid and dopaminergic responses. Arch Gen Psychiatry 65:220–231

    PubMed  Google Scholar 

  • Sehlmeyer C, Schöning S, Zwitserlood P, Pfleiderer B, Kircher T, Arolt V, Konrad C (2009) Human fear conditioning and extinction in neuroimaging: a systematic review. PLoS ONE 4:e5865

    PubMed  PubMed Central  Google Scholar 

  • Sloots CE, Felt-Bersma RJ, Cuesta MA, Meuwissen SG (2000) Rectal visceral sensitivity in healthy volunteers: influences of gender, age and methods. Neurogastroenterol Motil 12:361–368

    PubMed  CAS  Google Scholar 

  • Soffer EE, Kongara K, Achkar JP, Gannon J (2000) Colonic motor function in humans is not affected by gender. Dig Dis Sci 45:1281–1284

    PubMed  CAS  Google Scholar 

  • Swider K, Babel P (2013) The effect of the sex of a model on nocebo hyperalgesia induced by social observational learning. Pain 154:1312–1317

    PubMed  Google Scholar 

  • Talley NJ (2008) Functional gastrointestinal disorders as a public health problem. Neurogastroenterol Motil 20(Suppl 1):121–129

    PubMed  Google Scholar 

  • Tanaka Y, Kanazawa M, Fukudo S, Drossman DA (2011) Biopsychosocial model of irritable bowel syndrome. J Neurogastroenterol Motil 17:131–139

    PubMed  PubMed Central  Google Scholar 

  • Theysohn N, Schmid J, Icenhour A, Mewes C, Forsting M, Gizewski ER, Schedlowski M, Elsenbruch S, Benson S (2014) Are there sex differences in placebo analgesia during visceral pain processing? - a fMRI study in healthy subjects. Neurogastroenterol Motil (in revision)

    Google Scholar 

  • Tyler K, Moriceau S, Sullivan RM, Greenwood-van Meerveld B (2007) Long-term colonic hypersensitivity in adult rats induced by neonatal unpredictable vs predictable shock. Neurogastroenterol Motil 19:761–768

    PubMed  CAS  PubMed Central  Google Scholar 

  • Unruh AM (1996) Gender variations in clinical pain experience. Pain 65:123–167

    PubMed  CAS  Google Scholar 

  • van Laarhoven AI, Vogelaar ML, Wilder-Smith OH, Van Riel PL, van de Kerkhof PC, Kraaimaat FW, Evers AW (2011) Induction of nocebo and placebo effects on itch and pain by verbal suggestions. Pain 152:1486–1494

    PubMed  Google Scholar 

  • Vase L, Robinson ME, Verne GN, Price DD (2003) The contributions of suggestion, desire, and expectation to placebo effects in irritable bowel syndrome patients. An empirical investigation. Pain 105:17–25

    PubMed  Google Scholar 

  • Vase L, Robinson ME, Verne GN, Price DD (2005) Increased placebo analgesia over time in irritable bowel syndrome (IBS) patients is associated with desire and expectation but not endogenous opioid mechanisms. Pain 115:338–347

    PubMed  Google Scholar 

  • Verne GN, Sen A, Price DD (2005) Intrarectal lidocaine is an effective treatment for abdominal pain associated with diarrhea-predominant irritable bowel syndrome. J Pain 6:493–496

    PubMed  CAS  Google Scholar 

  • Vögtle E, Barke A, Kroner-Herwig B (2013) Nocebo hyperalgesia induced by social observational learning. Pain 154:1427–1433

    PubMed  Google Scholar 

  • Wang Z, Bradesi S, Charles JR, Pang RD, Maarek JM, Mayer EA, Holschneider DP (2011) Functional brain activation during retrieval of visceral pain-conditioned passive avoidance in the rat. Pain 152:2746–2756

    PubMed  PubMed Central  Google Scholar 

  • Weimer K, Schulte J, Maichle A, Muth ER, Scisco JL, Horing B, Enck P, Klosterhalfen S (2012) Effects of ginger and expectations on symptoms of nausea in a balanced placebo design. PLoS ONE 7:e49031

    PubMed  CAS  PubMed Central  Google Scholar 

  • Whitehead WE, Palsson O, Jones KR (2002) Systematic review of the comorbidity of irritable bowel syndrome with other disorders: what are the causes and implications? Gastroenterology 122:1140–1156

    PubMed  Google Scholar 

  • Wiech K, Lin CS, Brodersen KH, Bingel U, Ploner M, Tracey I (2010) Anterior insula integrates information about salience into perceptual decisions about pain. J Neurosci 30:16324–16331

    PubMed  CAS  Google Scholar 

  • Williams AE, Rhudy JL (2007) The influence of conditioned fear on human pain thresholds: does preparedness play a role? J Pain 8:598–606

    PubMed  Google Scholar 

  • Yágüez L, Coen S, Gregory LJ, Amaro E, Altman C, Brammer MJ, Bullmore ET, Williams SC, Aziz Q (2005) Brain response to visceral aversive conditioning: a functional magnetic resonance imaging study. Gastroenterology 128:1819–1829

    PubMed  Google Scholar 

  • Zubieta JK, Bueller JA, Jackson LR, Scott DJ, Xu Y, Koeppe RA, Nichols TE, Stohler CS (2005) Placebo effects mediated by endogenous opioid activity on mu-opioid receptors. J Neurosci 25:7754–7762

    PubMed  CAS  Google Scholar 

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Authors and Affiliations

  1. Institute of Medical Psychology and Behavioral Immunobiology, University Hospital Essen, University of Duisburg-Essen, Essen, Germany

    Sigrid Elsenbruch

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  1. Sigrid Elsenbruch
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Correspondence to Sigrid Elsenbruch .

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  1. Neuroscience Department and National Institute of Neuroscience Labs, University of Turin Medical School, Turin, Italy

    Fabrizio Benedetti

  2. Department of Psychosomatic Medicine, University Hospitals Tuebingen, Tuebingen, Germany

    Paul Enck

  3. Neuroscience Department and National Institute of Neuroscience Labs, University of Turin Medical School, Turin, Italy

    Elisa Frisaldi

  4. Institute of Medical Psychology and Behavioral Immunobiology, University Hospital Essen, Essen, Germany

    Manfred Schedlowski

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Elsenbruch, S. (2014). How Positive and Negative Expectations Shape the Experience of Visceral Pain. In: Benedetti, F., Enck, P., Frisaldi, E., Schedlowski, M. (eds) Placebo. Handbook of Experimental Pharmacology, vol 225. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-662-44519-8_6

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