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Ca2+ Signalling by IP3 Receptors

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Book cover Phosphoinositides II: The Diverse Biological Functions

Part of the book series: Subcellular Biochemistry ((SCBI,volume 59))

Abstract

The Ca2 + signals evoked by inositol 1,4,5-trisphosphate (IP3) are built from elementary Ca2 + release events involving progressive recruitment of IP3 receptors (IP3R), intracellular Ca2 + channels that are expressed in almost all animal cells. The smallest events (‘blips’) result from opening of single IP3R. Larger events (‘puffs’) reflect the near-synchronous opening of a small cluster of IP3R. These puffs become more frequent as the stimulus intensity increases and they eventually trigger regenerative Ca2 + waves that propagate across the cell. This hierarchical recruitment of IP3R is important in allowing Ca2 + signals to be delivered locally to specific target proteins or more globally to the entire cell. Co-regulation of IP3R by Ca2 + and IP3, the ability of a single IP3R rapidly to mediate a large efflux of Ca2 + from the endoplasmic reticulum, and the assembly of IP3R into clusters are key features that allow IP3R to propagate Ca2 + signals regeneratively. We review these properties of IP3R and the structural basis of IP3R behavior.

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Acknowledgements

Supported by the Wellcome Trust, Medical Research Council UK and Biotechnology and Biological Sciences Research Council UK. DLP is a Meres Senior Research Associate of St John’s College, Cambridge.

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  1. Department of Pharmacology, Tennis Court Road, CB2 1PD, Cambridge, UK

    Colin W. Taylor & David L. Prole

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  1. Colin W. Taylor
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Correspondence to Colin W. Taylor .

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  1. , NICHD, National Institutes of Health, Convent Drive 49, Bethesda, 20892-4480, Maryland, USA

    Tamas Balla

  2. , Cancer- and Immunobiology, University of Basel, Mattenstrasse 28, Basel, 4058, Switzerland

    Matthias Wymann

  3. , Pharmacology and Cancer Biology, Duke University Medical Center, Durham, 27710, North Carolina, USA

    John D. York

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Taylor, C.W., Prole, D.L. (2012). Ca2+ Signalling by IP3 Receptors. In: Balla, T., Wymann, M., York, J. (eds) Phosphoinositides II: The Diverse Biological Functions. Subcellular Biochemistry, vol 59. Springer, Dordrecht. https://doi.org/10.1007/978-94-007-3015-1_1

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