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Enhanced elevation of corticosterone following arecoline administration to rats selectively bred for increased cholinergic function

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Abstract

Serum corticosterone levels were determined following administration of the cholinergic agonist arecoline (4 mg/kg) to rats selectively bred for differences in cholinergic function. The Flinders Sensitive Line (FSL) of rats exhibited both greater suppression of behavioural activity and enhanced elevation fo serum corticosterone than the Flinders Resistant Line of rats. These enhanced responses to arecoline in the FSL rats parallel those reported in depressed humans, suggesting that these rats may provide a new animal model of affective disorders.

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References

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Authors and Affiliations

  1. School of Biological Sciences, The Flinders University of South Australia, 5042, Bedford Park, South Australia, Australia

    David H. Overstreet

  2. Department of Pharmacology, Center for Health Sciences, University of California, 90024, Los Angeles, CA, USA

    Ruth A. Booth

  3. Department of Psychiatry M-003, University of California at San Diego, 92093, La Jolla, CA, USA

    Richard Dana, S. Craig Risch & David S. Janowsky

Authors
  1. David H. Overstreet
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  2. Ruth A. Booth
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  3. Richard Dana
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  4. S. Craig Risch
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  5. David S. Janowsky
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Overstreet, D.H., Booth, R.A., Dana, R. et al. Enhanced elevation of corticosterone following arecoline administration to rats selectively bred for increased cholinergic function. Psychopharmacologia 88, 129–130 (1986). https://doi.org/10.1007/BF00310528

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  • DOI: https://doi.org/10.1007/BF00310528

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