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Etonitazene as a reinforcer: Oral intake of etonitazene by rhesus monkeys

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Abstract

Drinking of etonitazene HCl was studied in three rhesus monkeys during daily 3-h sessions. As the drug concentration was increased, the number of liquid deliveries decreased, and etonitazene intake (μg/kg body weight) increased. As fixed-ratio (FR) requirements were increased, rate of responding increased, and liquid deliveries slightly decreased. When water was substituted for the drug, there was a large increase in responding for several sessions, followed by a slow decline to low rates. When etonitazene was reintroduced, responding abruptly increased to previous drug levels. These data suggest that etonitazene can serve as a positive reinforcer when taken orally by rhesus monkeys.

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Carroll, M.E., Meisch, R.A. Etonitazene as a reinforcer: Oral intake of etonitazene by rhesus monkeys. Psychopharmacology 59, 225–229 (1978). https://doi.org/10.1007/BF00426626

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  • DOI: https://doi.org/10.1007/BF00426626

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