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Selective suppression of some components of spontaneous activity in various types of smooth muscle by iproveratril (verapamil)

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Summary

Intra- and extracellular measurements of electrical activity were recorded simultaneously with tension development from isolated preparations of taenia coli, portal vein, stomach and ureter of the guinea-pig. Iproveratril (verapamil) inhibits electrical and mechanical activity in parallel in spontaneously active preparations of taenia coli and portal vein. Spike discharges and second-rhythm (SR) oscillations are both suppressed in the electrical activity. In portal vein, the relatively weak basic organ specific rhythm (BOR) of this tissues is also suppressed. The minute-rhythm (MR) appears less sensitive or resistant to iproveratril. In ureter and antrum preparations of the stomach there is an additional iproveratril resistant component: the basic electrical process of stomach and ureter peristalsis which, in the classification of smooth muscle rhythms, belongs to the type BOR. The superimposed spike potentials of the antrum and the spike-like oscillations of the ureter action potential are inhibited similarly as are the spike potentials in taenia coli and portal vein. The similarity between the iproveratril effects and the effect of Ca-deprivation indicates a Ca-antagonistic action of iproveratril. Conclusions concerning the hypothesis of “Ca-spikes” in smooth muscle are discussed.

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References

  • Bozler, E.: The action potentials accompanying conducted responses in visceral smooth muscles. Amer. J. Physiol.136, 553–560 (1942).

    Google Scholar 

  • Brading, A., Bülbring, E., Tomita, T.: The effect of sodium and calcium on the action potential of the smooth muscle of the guinea-pig taenia coli. J. Physiol. (Lond.)200, 637–654 (1969).

    Google Scholar 

  • Bülbring, E., Kuriyama, H.: Effects of changes in the external sodium and calcium concentrations on spontaneous electrical activity in smooth muscle of guinea-pig taenia coli. J. Physiol. (Lond.)166, 29–58 (1963).

    Google Scholar 

  • —, Tomita, T.: Effects of Ca removal on the smooth muscle of the guinea-pig taenia coli. J. Physiol. (Lond.)210, 217–232 (1970).

    Google Scholar 

  • Fleckenstein, A., Döring, H. J., Kammermeier, H.: Einfluß von Beta-Receptoren-blockern und verwandten Substanzen auf Erregung, Kontraktion und Energiestoffwechsel der Myokardfaser. Klin. Wschr.46, 343–351 (1968).

    Google Scholar 

  • —, Grün, G., Tritthart, H., Byon, K.: Uterus-Relaxation durch hochaktive Ca++-antagonistische Hemmstoffe der elektro-mechanischen Koppelung wie Isoptin (Verapamil, Iproveratril), Substanz D 600 und Segontin (Prenylamin). Klin. Wschr.49, 32–41 (1971).

    Google Scholar 

  • —, Kammermeier, H., Döring, H. J., Freund, H. J.: Zum Wirkungsmechanismus neuartiger Koronardilatatoren mit gleichzeitig Sauerstoff-einsparenden Myokard-Effekten, Prenylamin und Iproveratril. Z. Kreisl.-Forsch.56, 716–744, 839–858 (1967).

    Google Scholar 

  • —, Tritthart, H., Fleckenstein, B., Herbst, A., Grün, G.: Eine neue Gruppe kompetitiver Ca++-Antagonisten (Iproveratril, D 600, Prenylamin) mit starken Hemmeffekten auf die elektromechanische Koppelung im Warmblüter-Myokard. Pflügers Arch.307, R25 (1969).

    Google Scholar 

  • Golenhofen, K.: Slow rhythms in smooth muscle (minute-rhythm). In: E. Bülbring et al. (Ed.): Smooth muscle, pp. 316–342. London: Ed. Arnold Ltd. 1970.

    Google Scholar 

  • —: Physiologie der Uretermuskulatur. In: W. Lutzeyer u. H. Melchior (Hrsg.): Ureterdynamik, S. 46–59. Stuttgart: G. Thieme 1971.

    Google Scholar 

  • —, Loh, D. v.: Elektrophysiologische Untersuchungen zur normalen Spontanaktivität der isolierten Taenia coli des Meerschweinchens. Pflügers Arch.314, 312–328 (1970a).

    Google Scholar 

  • Golenhofen, K., Loh, D. v.: Intracelluläre Potentialmessungen zur normalen Spontanaktivität der isolierten Portalvene des Meerschweinchens. Pflüers Arch.319, 82–100 (1970b).

    Google Scholar 

  • ——, Milenov, K.: Elektrophysiologische Untersuchungen zur Spontanaktivität isolierter Muskelpräparate aus vershiedenen Abschnitten des Meerschweinchen-Magens. Pflügers Arch.315, 336–356 (1970).

    Google Scholar 

  • —, Petrányi, P.: Spikes of smooth muscle in calcium-free solution (isolated taenia coli of the guinea-pig). Experientia (Basel)25, 271–273 (1969).

    Google Scholar 

  • Kuriyama, H., Osa, T., Toida, N.: Membrane properties of the smooth muscle of guinea-pig ureter. J. Physiol. (Lond.)191, 225–238 (1967).

    Google Scholar 

  • —, Tomita, T.: The action potential in the smooth muscle of the guinea pig taenia coli and ureter studied by double sucrose-gap method. J. gen. Physiol.55, 147–162 (1970).

    Google Scholar 

  • Lammel, E., Golenhofen, K.: Messungen der45Ca-Aufnahme an intestinaler glatter Muskulatur zur Hypothese eines von Ca-Ionen getragenen Aktionsstromes. Pflügers Arch.329, 269–282 (1971).

    Google Scholar 

  • ——: Erregbarkeit und Ca-Austausch intestinaler glatter Muskulatur (Taenia coli des Meerschweinchens) unterhalb der kritischen Temperatur für die Spontanaktivität. Pflügers Arch.329, 258–268 (1971).

    Google Scholar 

  • Loh, D. v., Golenhofen, K.: Temperatureinflüsse auf die Spontanaktivität der isolierten Taenia coli vom Meerschweinchem. Pflügers Arch.318, 35–50 (1970).

    Google Scholar 

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Golenhofen, K., Lammel, E. Selective suppression of some components of spontaneous activity in various types of smooth muscle by iproveratril (verapamil). Pflugers Arch. 331, 233–243 (1972). https://doi.org/10.1007/BF00589130

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