Skip to main content
Log in

Tumor markers in patients with advanced breast cancer as prognosticators: A preliminary study

  • Brief communication
  • Published:
Breast Cancer Research and Treatment Aims and scope Submit manuscript

Summary

A retrospective study was performed on 69 breast cancer patients (stage II, N=18; advanced disease, N=51) in order to assess the prognostic value of circulating prolactin (PRL), CEA, CA 15-3, insulin-like growth factor-1 (IGF-1), and epidermal growth factor (EGF) by RIA/IRMA. These markers were compared with short-term prognosis (two years). Significant difference was observed only for PRL (<20.0 ng/ml vs. >20.0 ng/ml), which provide an independent predictor of short-term prognosis in advanced breast cancer.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

References

  1. Spyratos F, Hacene K, Tubiana-Hulin M, Pallud C, Brunet M: Prognostic value of estrogen and progesterone receptors in primary infiltrating ductal breast cancer. A sequential multivariate analysis of 1262 patients. Eur J Cancer Clin Oncol 8:1233–1240, 1989

    Google Scholar 

  2. McGuire WL: Steroid receptors in human breast cancer. Cancer Res 38:4289–4291, 1978

    Google Scholar 

  3. Grimaux M, Romain S, Remvikos Y, Martin PM, Magdelenat H: Prognostic value of epidermal growth factor receptor in node-positive breast cancer. Breast Cancer Res Treat 14:77–90, 1989

    Google Scholar 

  4. Toi M, Nakamura H, Wada T, Osaki A, Yamada H, Toge T, Niimoto M, Hattori T: Relationship between epidermal growth factor receptor status and various prognostic factors in human breast cancer. Cancer 65:1980–1984, 1990

    Google Scholar 

  5. Gullick WJ, Berger MS, Bannett PLP, Rothbard JB, Waterfield MD: Expression of the c erb B2 protein in normal and transformed cells. Int J Cancer 40: 246–254, 1987

    Google Scholar 

  6. Rochefort H: Cathepsin D in breast cancer. Breast Cancer Res Treat 16:3–13, 1990

    Google Scholar 

  7. Foekens JA, Portengen H, Janssen M, Klijn JGM: Insulin-like growth factor-1 receptors and insulin-like growth factor-1-like activity in human primary breast cancer. Cancer 63:2139–2147, 1989

    Google Scholar 

  8. Bhatavdekar JM, Giri DD, Shah NG, Trivedi SN, Patel DD, Karelia NH, Balar DB, Bhaduri A, Vora HH, Ghosh N, Shukla MK: Prolactin in advanced breast carcinoma — An Indian experience. Breast Disease 3:199–204, 1990

    Google Scholar 

  9. Bhatavdekar JM, Shah NG, Balar DB, Patel DD, Bhaduri A, Trivedi SN, Karelia NH, Ghosh N, Shukla MK, Giri DD: Plasma prolactin as an indicator of disease progression in advanced breast cancer. Cancer 65:2028–2032, 1990

    Google Scholar 

  10. Bhatavdekar JM, Patel DD, Giri DD, Shah NG, Karelia NH, Vora HH, Trivedi SN, Ghosh N, Suthar TP, Balar DB: Plasma prolactin and prognosis in advanced breast cancer. Breast Disease 6:107–111, 1993

    Google Scholar 

  11. International Union against Cancer. TNM classification of malignant tumors. UICC technical report series 51, 1980

  12. Bloom HJG, Richardson WW: Histological grading and prognosis in breast cancer. Br J Cancer 11:359–377, 1957

    Google Scholar 

  13. Kaplan EL, Meier P: Non parametric estimation from incomplete observations. J Am Stat Assoc 53:457–481, 1958

    Google Scholar 

  14. Schmidt-Rhode P, Schulz KD, Sturm G, Raab-Frick A, Prinz H: CA 15.3 as a tumor marker in breast cancer. Int J Biol Markers 2:135–142, 1987

    Google Scholar 

  15. Bhatavdekar JM, Balar DB, Shah NG, Trivedi SN, Bhaduri A, Patel DD, Karelia NH, Shukla MK, Ghosh N: Prognosis in breast carcinoma utilizing plasma carcinoembryonic antigen and histologic characteristics of the primary tumor. Tumor Biol 8:233–240, 1987

    Google Scholar 

  16. Bhatavdekar JM, Trivedi SN, Shah NG, Patel DD, Karelia NH, Shukla MK, Ghosh N, Vora HH: Comparison of prolactin, CA 15-3 and TPA in breast carcinomas. Int J Biol Markers 4:150–156, 1989

    Google Scholar 

  17. Wang DY, Hamed H, Mockridge CI, Fentiman IS: Radioimmunoassayable insulin-like growth factor-1 in human breast cystic fluid. Eur J Cancer Clin Oncol 25:867–872, 1989

    Google Scholar 

  18. Boccardo F, Torrisi R, Zanardi S, Valenti G, Pensa F, De Franchis V, Barreca A, Ferraro P, Minuto F: EGF in breast cyst fluid: Relationship with intracystic androgens, estradiol and progesterone. Int J Cancer 47:523–526, 1991

    Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Rights and permissions

Reprints and permissions

About this article

Cite this article

Bhatavdekar, J., Patel, D., Karelia, N. et al. Tumor markers in patients with advanced breast cancer as prognosticators: A preliminary study. Breast Cancer Res Tr 30, 293–297 (1994). https://doi.org/10.1007/BF00665970

Download citation

  • Issue Date:

  • DOI: https://doi.org/10.1007/BF00665970

Key words

Navigation