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Critical sulfhydryls regulate calcium release from sarcoplasmic reticulum

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Abstract

Rapid Ca2+ release from the sarcoplasmic reticulum (SR) can be triggered by either binding of heavy metals to a sulfhydryl (SH) group or by catalyzing the oxidation of endogenous groups to a disulfide. Ca2+ release has been monitored directly using isolated vesicle preparations or indirectly by monitoring phasic contractions in a skinned fiber preparation. SH oxidation triggered by addition of Cu2+ /mercaptans, phthalocyanine dyes, reactive disulfides, and various anthraquinones appears to involve a direct interaction with the Ca2+ release protein from the SR. A model is presented in which reversible oxidation and reduction of endogenous SH groups results in the opening and closing of the Ca2+ release channel from the SR.

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Abbreviations

SR:

sarcoplasmic reticulum

SH:

sulfhydryl

T-tubule:

transverse tubule

2,2′-DTDP:

2,2′-dithiodipyridine

4,4′-DTDP:

4,4′-dithiodipyridine

DTT:

dithiothreitol

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Abramson, J.J., Salama, G. Critical sulfhydryls regulate calcium release from sarcoplasmic reticulum. J Bioenerg Biomembr 21, 283–294 (1989). https://doi.org/10.1007/BF00812073

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