Abstract
Rapid Ca2+ release from the sarcoplasmic reticulum (SR) can be triggered by either binding of heavy metals to a sulfhydryl (SH) group or by catalyzing the oxidation of endogenous groups to a disulfide. Ca2+ release has been monitored directly using isolated vesicle preparations or indirectly by monitoring phasic contractions in a skinned fiber preparation. SH oxidation triggered by addition of Cu2+ /mercaptans, phthalocyanine dyes, reactive disulfides, and various anthraquinones appears to involve a direct interaction with the Ca2+ release protein from the SR. A model is presented in which reversible oxidation and reduction of endogenous SH groups results in the opening and closing of the Ca2+ release channel from the SR.
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Abbreviations
- SR:
-
sarcoplasmic reticulum
- SH:
-
sulfhydryl
- T-tubule:
-
transverse tubule
- 2,2′-DTDP:
-
2,2′-dithiodipyridine
- 4,4′-DTDP:
-
4,4′-dithiodipyridine
- DTT:
-
dithiothreitol
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Abramson, J.J., Salama, G. Critical sulfhydryls regulate calcium release from sarcoplasmic reticulum. J Bioenerg Biomembr 21, 283–294 (1989). https://doi.org/10.1007/BF00812073
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DOI: https://doi.org/10.1007/BF00812073