Summary
Haloperidol (30 nM, 3 μM) was found to increase prolactin release from GH4C 1 cells transfected with the D 2 receptor cDNA (GH4ZR 7) and from wild-type (untransfected) GH 3 cells, but not from wild-type GH4C 1 cells. In addition, haloperidol (3 μM) stimulated cAMP formation in GH 3 cells. It is suggested that haloperidol may act as an inverse agonist rather than as a neutral antagonist at dopaminergic D 2 receptors.
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Nilsson, C.L., Eriksson, E. Haloperidol increases prolactin release and cyclic AMP formation in vitro: inverse agonism at dopamine D2 receptors?. J. Neural Transmission 92, 213–220 (1993). https://doi.org/10.1007/BF01244880
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DOI: https://doi.org/10.1007/BF01244880