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Locomotor inhibition by the D3 ligand R-(+)-7-OH-DPAT is independent of changes in dopamine release

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Summary

The dopamine D3 preferring ligand R-(+)-7-OH-DPAT induced strong hypolocomotion in rats. Doses producing reduction of locomotion failed to affect dopamine release or synthesis rate. These data support the hypothesis that the dopamine D3 receptor is a postsynaptic receptor with an inhibitory influence on rat locomotor activity.

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Author notes

  1. K. Svensson

    Present address: Department of Pharmacology, University of Göteborg, Göteborg, Sweden

Authors and Affiliations

  1. Department of Pharmacology, University of Göteborg, Göteborg, Sweden

    A. Carlsson & N. Waters

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  1. K. Svensson
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  2. A. Carlsson
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  3. N. Waters
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Svensson, K., Carlsson, A. & Waters, N. Locomotor inhibition by the D3 ligand R-(+)-7-OH-DPAT is independent of changes in dopamine release. J. Neural Transmission 95, 71–74 (1994). https://doi.org/10.1007/BF01283032

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  • DOI: https://doi.org/10.1007/BF01283032

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