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Genetic and pharmacological models of cholinergic supersensitivity and affective disorders

  • Multi-author Review
  • Genetic Models in Brain and Behavior Research, Part I
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Summary

Increased muscarinic sensitivity has been associated with altered hormonal states (hypothyroidism and hyperadrenocorticism), chronic administration of muscarinic antagonists or antidepressants with muscarinic actions, selective breeding for anticholinesterase sensitivity, and certain inbred strains of rats and mice. Thus, both genetic and environmental factors may influence muscarinic receptor sensitivity. The reasonably detailed studies on the selectively-bred rats have revealed that the Flinders Sensitive Line (FSL) rats weigh less, are less active, are more sensitive to muscarinic agonists and to stressors, and have higher concentrations of hippocampal and striatal muscarinic receptors than ‘normal’, or the selectively-bred, Flinders Resistant Line (FRL) rats. Thus, there are a number of parallels between FSL rats and depressed humans. The FSL rats may be the first animal model of depression to mimic the actual trait of depression, and not just the state.

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  1. Schools of Biological Sciences and Medicine, The Flinders University of South Australia, 5042, Bedford Park, South Australia, Australia

    D. H. Overstreet, R. W. Russell, A. D. Crocker & J. Ch Gillin

  2. Department of Psychiatry M-003, University of California at San Diego, 92093, La Jolla, California, USA

    D. S. Janowsky

  3. Department of Psychiatry, University of North Carolina, 27514, Chapel Hill, North Carolina, USA

    D. S. Janowsky

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Overstreet, D.H., Russell, R.W., Crocker, A.D. et al. Genetic and pharmacological models of cholinergic supersensitivity and affective disorders. Experientia 44, 465–472 (1988). https://doi.org/10.1007/BF01958920

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