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Influence of substance P and fragments on passive avoidance behavior

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Summary

N-terminal and C-terminal fragments of substance P (SP) have been shown to exert opposite effects on antinociception, grooming and fighting in mice. The present experiments explored whether these findings could be generalized to passive avoidance behavior. Substance P (SP-(1-11)) and the c-terminal, fragment pyroglutamyl-SP-(7-11) attenuated passive avoidance behavior when picogram amounts were injected into the nucleus accumbens. In contrast, the N-terminal fragment, SP-(1-7) had an opposite effect and facilitated passive avoidance behavior.

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Author notes

  1. J. M. Stewart

    Present address: Health Sciences Center, Denver, Colorado, USA

Authors and Affiliations

  1. Rudolf Magnus Institute for Pharmacology, Medical Faculty, University of Utrecht, Vondellaan 6, NL-3521 GD, Utrecht, The Netherlands

    O. Gaffori, J. M. Stewart & D. de Wied

  2. Health Sciences Center, University of Colorado, Denver, Colorado, USA

    O. Gaffori, J. M. Stewart & D. de Wied

Authors
  1. O. Gaffori
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  2. J. M. Stewart
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  3. D. de Wied
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Gaffori, O., Stewart, J.M. & de Wied, D. Influence of substance P and fragments on passive avoidance behavior. Experientia 40, 89–91 (1984). https://doi.org/10.1007/BF01959118

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