Summary
We evaluated the effect of hypoxia (7% v/v) on hepatic heme turnover in vivo and microsomal heme protein content in male Sprague-Dawley rats. Hepatic heme protein turnover, measured as14CO-production during continuous infusion of 5-14C-aminolevulinic acid, a precursor of nonerythrogenic heme, was decreased 60% during hypoxia and returned to control levels promptly after reoxygenation. Hepatic cytochrome P-450 content was decreased in hypoxic and 24-h reoxygenated animals. We conclude that normobaric hypoxia decreases hepatic cytochrome P-450 which could contribute to decreased drug metabolism in hypoxia. This decrease is probably due to heme oxygenase-independent breakdown of hepatic heme.
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Jordi-Racine, A.L., Alvarez, E. & Reichen, J. The effect of hypoxia on hepatic cytochromes and heme turnover in rats in vivo. Experientia 44, 343–345 (1988). https://doi.org/10.1007/BF01961276
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DOI: https://doi.org/10.1007/BF01961276