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Role of intracellular sodium activity in the control of contraction in cardiac purkinje fibers

  • Original Paper
  • Published:
Journal of Biomedical Science

Abstract

The role of intracellular sodium activity (a iNa ) in the control of force was studied in sheep cardiac Purkinje fibers exposed to norepinephrine (NE) and high [Ca]o in the absence and presence of overdrive or of a low concentration of strophanthidin. Both NE and high [Ca]o decrease a iNa and increase force, while overdrive increases and low strophanthidin decreases both parameters. In the presence of NE, overdrive increases a iNa less than force and is followed by a more pronounced undershoot in a iNa and force. In contrast, in high [Ca]o overdrive increases a iNa more than force and is followed by a less pronounced undershoot in a iNa and force than in NE. High [Ca]o increases force to a peak, but then the decreasing a iNa reduces force. In all these conditions, a iNa determines force changes during recovery from overdrive. NE and high [Ca]o decrease a iNa less and increase force more in low strophanthidin. Thus, changes in a iNa modulate the increase in force due to increased Ca influx and control force development when Ca influx is either unchanged (low strophanthidin) or has reached a steady state (high [Ca]o, recovery from overdrive).

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Authors and Affiliations

  1. Department of Physiology, SUNY, HSC, 450 Clarkson Avenue, Box 31, 11203, Brooklyn, NY, USA

    P. Abete &  M. Vassalle

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  1. P. Abete
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  2. M. Vassalle
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Abete, P., Vassalle, M. Role of intracellular sodium activity in the control of contraction in cardiac purkinje fibers. J Biomed Sci 1, 28–42 (1993). https://doi.org/10.1007/BF02258337

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  • DOI: https://doi.org/10.1007/BF02258337

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