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Mechanisms of synaptic depression triggered by metabotropic glutamate receptors

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Abstract.

Glutamate, by activation of metabotropic receptors (mGluRs), can lead to a reduction of synaptic efficacy at many synapses. These forms of synaptic plasticity are referred to as long-term depression (mGluR-LTD). We will distinguish between mGluR-LTD induced by pre- or postsynaptic receptors and mGluR-LTD induced by the locus of the expression mechanism of the synaptic depression. We will also review recent evidence that mGluR-mediated responses themselves are subject to depression, which may constitute a form of metaplasticity.

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Correspondence to C. Lüscher.

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Received 13 May 2008; received after revision 07 July 2008; accepted 11 July 2008

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Bellone, C., Lüscher, C. & Mameli, M. Mechanisms of synaptic depression triggered by metabotropic glutamate receptors. Cell. Mol. Life Sci. 65, 2913–2923 (2008). https://doi.org/10.1007/s00018-008-8263-3

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  • DOI: https://doi.org/10.1007/s00018-008-8263-3

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