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Adenosine—a physiological or pathophysiological agent?

  • Molecules in Medicine
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Abstract

This minireview briefly summarizes the evidence that adenosine, acting on four G-protein coupled receptors, can play physiological roles, but is also critically involved in pathological processes. The factors that decide which of these is the more important in a specific cell or organ are briefly summarized. The fact that drugs that target adenosine receptors in disease will also hit the physiological processes will make drug development more tricky.

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  1. Department of Physiology and Pharmacology, Karolinska Institutet, S-17177, Stockholm, Sweden

    Bertil B. Fredholm

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Correspondence to Bertil B. Fredholm.

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Fredholm, B.B. Adenosine—a physiological or pathophysiological agent?. J Mol Med 92, 201–206 (2014). https://doi.org/10.1007/s00109-013-1101-6

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  • DOI: https://doi.org/10.1007/s00109-013-1101-6

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