Skip to main content
SpringerLink
Log in

Lipopolysaccharide induces sCD40L release through human platelets TLR4, but not TLR2 and TLR9

  • Correspondence
  • Published:
Intensive Care Medicine Aims and scope Submit manuscript

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Fig. 1

References

  1. Inwald DP, Faust SN, Lister P, Peters MJ, Levin M, Heyderman R, Klein NJ (2006) Platelet and soluble CD40L in meningococcal sepsis. Intensive Care Med 32:1432–1437

    Article  PubMed  Google Scholar 

  2. Elzey BD, Tian J, Jensen RJ, Swanson AK, Lees JR, Lentz SR, Stein CS, Nieswandt B, Wang Y, Davidson BL, Ratliff TL (2003) Platelet-mediated modulation of adaptive immunity. A communication link between innate and adaptive immune compartments. Immunity 19:9–19

    Article  PubMed  CAS  Google Scholar 

  3. Freedman JE (2003) CD40-CD40L and platelet function: beyond hemostasis. Circ Res 92:944–946

    Article  PubMed  CAS  Google Scholar 

  4. Cognasse F, Hamzeh H, Chavarin P, Acquart S, Genin C, Garraud O (2005) Evidence of Toll-like receptor molecules on human platelets. Immunol Cell Biol 83:196–198

    Article  PubMed  CAS  Google Scholar 

  5. Damas JK, Jensenius M, Ueland T, Otterdal K, Yndestad A, Froland SS, Rolain JM, Myrvang B, Raoult D, Aukrust P (2006) Increased levels of soluble CD40L in African tick bite fever: possible involvement of TLRs in the pathogenic interaction between Rickettsia africae, endothelial cells, and platelets. J Immunol 177:2699–2706

    PubMed  CAS  Google Scholar 

Download references

Acknowledgements

This study was supported by the EFS Auvergne-Loire and the Association Recherche Transfusion (ART-No 43-2006).

Author information

Authors and Affiliations

  1. EFS Auvergne-Loire, Université de Saint-Etienne, Faculté de Médecine, 15 rue Ambroise Paré, 42023, Saint-Etienne cedex 2, France

    Fabrice Cognasse, Sandrine Lafarge, Patricia Chavarin, Sophie Acquart & Olivier Garraud

  2. GIMAP-EA3064, Université de Saint-Etienne, Faculté de Médecine, 15 rue Ambroise Paré, 42023, Saint-Etienne cedex 2, France

    Fabrice Cognasse, Sandrine Lafarge & Olivier Garraud

Authors
  1. Fabrice Cognasse
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Sandrine Lafarge
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Patricia Chavarin
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. Sophie Acquart
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. Olivier Garraud
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Olivier Garraud.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Cognasse, F., Lafarge, S., Chavarin, P. et al. Lipopolysaccharide induces sCD40L release through human platelets TLR4, but not TLR2 and TLR9. Intensive Care Med 33, 382–384 (2007). https://doi.org/10.1007/s00134-006-0488-8

Download citation

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s00134-006-0488-8

Keywords

Search

Navigation